,Neonatal infection: antibiotics for prevention and treatment (NG195)
Your responsibility
The recommendations in this guideline represent the view of NICE, arrived at after careful
consideration of the evidence available. When exercising their judgement, professionals
and practitioners are expected to take this guideline fully into account, alongside the
individual needs, preferences and values of their patients or the people using their service.
It is not mandatory to apply the recommendations, and the guideline does not override the
responsibility to make decisions appropriate to the circumstances of the individual, in
consultation with them and their families and carers or guardian.
All problems (adverse events) related to a medicine or medical device used for treatment
or in a procedure should be reported to the Medicines and Healthcare products Regulatory
Agency using the Yellow Card Scheme.
Local commissioners and providers of healthcare have a responsibility to enable the
guideline to be applied when individual professionals and people using services wish to
use it. They should do so in the context of local and national priorities for funding and
developing services, and in light of their duties to have due regard to the need to eliminate
unlawful discrimination, to advance equality of opportunity and to reduce health
inequalities. Nothing in this guideline should be interpreted in a way that would be
inconsistent with complying with those duties.
Commissioners and providers have a responsibility to promote an environmentally
sustainable health and care system and should assess and reduce the environmental
impact of implementing NICE recommendations wherever possible.
Who is it for? ........................................................................................................................................... 5
1.1 Information and support ................................................................................................................... 6
1.2 Preventing early-onset neonatal infection before birth................................................................ 11
1.3 Risk factors for and clinical indicators of possible early-onset neonatal infection ................... 14
Kaiser Permanente neonatal sepsis calculator ................................................................................... 18
Management for babies at increased risk of infection ....................................................................... 19
1.4 Investigations before starting antibiotics in babies who may have early-onset infection ........ 20
1.5 Antibiotics for suspected early-onset infection ............................................................................ 24
1.6 Duration of antibiotic treatment for early-onset neonatal infection ............................................ 25
1.7 Antibiotic-impregnated intravascular catheters for reducing the risk of late-onset neonatal
infection .................................................................................................................................................. 27
1.8 Risk factors for and clinical indicators of possible late-onset neonatal infection ...................... 28
1.9 Investigations before starting antibiotics in babies who may have late-onset infection .......... 30
1.10 Antibiotics for late-onset neonatal infection ................................................................................ 33
1.11 Duration of antibiotic treatment for late-onset neonatal infection ............................................. 34
1.12 Antifungals to prevent fungal infection during antibiotic treatment for late-onset neonatal
infection .................................................................................................................................................. 36
1.13 Avoiding routine use of antibiotics in babies................................................................................ 37
1.14 Early- and late-onset meningitis (babies in neonatal units) ....................................................... 37
1.15 Therapeutic drug monitoring for babies receiving gentamicin................................................... 44
1.16 Care setting ..................................................................................................................................... 45
1.17 Planning for care after discharge .................................................................................................. 45
Terms used in this guideline.................................................................................................................. 46
Recommendations for research ................................................................................................. 48
Key recommendations for research ..................................................................................................... 48
Other recommendations for research .................................................................................................. 49
Women with prolonged prelabour rupture of membranes who have group B streptococcal
colonisation, bacteriuria or infection .................................................................................................... 57
Risk factors for and clinical indicators of possible early-onset neonatal infection ......................... 58
Cerebrospinal fluid investigations in babies with suspected bacterial meningitis .......................... 62
Antibiotic-impregnated intravascular catheters for reducing the risk of late-onset neonatal
infection .................................................................................................................................................. 63
Risk factors for and clinical indicators of possible late-onset neonatal infection ........................... 64
Investigations for late-onset neonatal infection ................................................................................. 66
Antibiotics for late-onset neonatal infection ....................................................................................... 68
Antifungals to prevent fungal infection during antibiotic treatment for late-onset neonatal
infection .................................................................................................................................................. 70
Early- and late-onset meningitis (babies in neonatal units) .............................................................. 71
Fluid restriction for confirmed bacterial meningitis ............................................................................ 71
Assessing for immunodeficiency and recurrence risk in babies with bacterial meningitis............. 72
Identifying and managing complications ............................................................................................. 73
Planning for care after discharge ......................................................................................................... 74
Care after hospital discharge ................................................................................................................ 75
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller shifuexperttutor. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $15.99. You're not tied to anything after your purchase.
