Exam (elaborations)
BMTCN Exam Questions and Correct Answers
- Course
- Institution
BMTCN Exam Questions and Correct Answers
[Show more]
Content preview
BMTCNWhat type of transplants commonly have PTLD as a secondary malignancy? - Answer -Allo HSCT with T-
cell depleted graft
Therapies associated with therapy-related acute leukemia and MDS - Answer -alkylating agents (eg.
Cytoxan, cisplatin, melphalan, busulfan, ifos) , radiation, topoisomerase II inhibitors (eg. doxorubicin,
etoposide, mitoxantrone)
Genetic predispositions that increase risk of primary and secondary cancers - Answer -neurofibromatosis
type 1, Fanconi anemia
Risk factors for PTLD - Answer -T-cell depleted graft, mismatched related or unrelated donor.
Busulfan, ATG, mAbs, TBI
patient w/ primary immunodeficiency, acute or extensive GVHD, EBV
Risk factors for secondary solid tumors - Answer -younger age at HSCT, TBI, chronic GVHD, increasing
time from transplant, infections, genetic predisposition, lifestyle factors
Treatment options for PTLD - Answer -EBV-specific cytotoxic T cells, mAbs targeted to B cells (rituximab),
combination chemotherapy
, Treatment options for secondary MDS/acute leukemia - Answer -conventional chemo or allo transplant.
Poor outcomes.
QOL domains - Answer -Physical, Functional, Psychological, Social, Spiritual/existential, Multiple
interactions between domains
Altered sexual health in male HSCT survivors - Answer -damage to the hypothalamic-pituitary-gonadal
axis: elevated FSH, elevated LH, low testosterone levels; cavernosal arterial insufficiency causing ED
Altered sexual health in female HSCT survivors - Answer -alkylating agents and radiation cause infertility
and premature ovarian failure, elevated FSH and LG, low estradiol, menopausal symptoms
Risk factors for vaginal alterations post transplant - Answer -POF (premature ovarian failure), TBI,
chronic GVHD
Risk factors for infertility - Answer -pre-HSCT antineoplastic therapy, exposure to alkylating agents, TBI
or pelvic irradiation, older age
Pregnancy risks in HSCT survivors - Answer -increased risk of preterm birth and low birth weight, cardiac
decompensation during pregnancy 2/2 prior anthracycline exposure. Similar rate of spontaneous
abortion to general population.
Recommended vaccines - Answer -Pneumococcal, Diptheria-tetanus, Pertussis, Meningococcal,
Inactivated polio
Hep B, Recombinant Hep A, Influenza, Measles Mumps and Rubells, HPV
When can HSCT survivors get vaccines? - Answer -inactive vaccines start at 6 months post HSCT, live
vaccines start at 2 years post HSCT (in absence of ongoing immunosuppression and GVHD)
Most common secondary malignancy in pediatric patients who received radiatios? - Answer -
Nonsquamous call carcinoma
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Zanaya. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
79223 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now