Dosing and Administration
Drug name (pt. should be aware of trade & generic)
Dosage Schedule of Admin (pt. should know how & when to take drug)
Pt. Adherence (compliance/concordance)
Technique of Administration (pt. must be taught how to admin.)
Duration of Drug Use (pt. must know when to stop meds.)
Drug Storage
how to promote therapeutic effects?
-inform pts. the nature & time course of expected beneficial effects
-teach pts. about nondrug measures to increase chances of success
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How to minimize adverse effects?
give your pt. knowledge of adverse drug effects
what is a chemical name?
a description of a drug using the nomenclature of chemistry
,what is the generic name?
(nonproprietary name)
indicates a drug's pharmacologic class
What is a brand name?
(proprietary/trade name)
name under which a drug is marketed
what is pharmacokinetics?
study of drug movement throughout the body
what is absorption?
movement of a drug from its site of admin. into the blood
what is the rate of absorption?
how soon effects will begin
what is the amount of absorption?
how intense effects will be
IV?
Intravenous
IM?
Intramuscular
subQ?
Subcutaneous
PO?
Oral
what is distribution?
, drug movement from the blood to the interstitial space of tissues & from there into cells
After a drug has been delivered to an organ or tissue via the blood, whats the next step?
exit the vasculature
why is exiting the vascular system important?
-most drugs dont produce their effects within the blood
-allows drugs to undergo metabolism & excretion
What is blood-brain barrier (BBB)?
unique anatomy of capillaries in the CNS
What is metabolism (biotransformation) ?
chemical alteration of drug structure
What are the therapeutic consequences of drug metabolism?
1)accelerated renal excretion of drugs
2)drug inactivation
3)increased therapeutic action
4)activation of "prodrugs"
5)increased toxicity
6)decreased toxicity
What is first-pass effect?
The rapid hepatic inactivation of certain oral drugs
What is excretion?
The removal of drugs from the body.
Routes of excretion?
-urine
-bile
-sweat
-saliva
-breast milk
-expired air
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