NRNP 6566 |Drug Metabolism| Midterm Practice Questions and Answers |100% Correct| Latest Version 2024/2025
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NRNP 6566 |Drug Metabolism| Midterm
Practice Questions and Answers |100%
Correct| Latest Version 2024/2025
Describe cytochrome p450 system Cytochrome p450 system is a series of enzymes used to
metabolize medications
Explain the role of cytochrome P450 enzymes in drug metabolism.
Cytochrom...
NRNP 6566 |Drug Metabolism| Midterm
Practice Questions and Answers |100%
Correct| Latest Version 2024/2025
Describe cytochrome p450 system Cytochrome p450 system is a series of enzymes used to
metabolize medications
Explain the role of cytochrome P450 enzymes in drug metabolism.
Cytochrome P450 enzymes are crucial for the biotransformation of drugs, facilitating their
conversion into more water-soluble forms for excretion.
What is the significance of substrate specificity in cytochrome P450 enzymes?
Substrate specificity ensures that each enzyme selectively metabolizes specific compounds,
minimizing unwanted drug interactions.
How do genetic polymorphisms affect cytochrome P450 enzyme activity?
Genetic polymorphisms can lead to variations in enzyme activity, resulting in differences in
drug metabolism among individuals.
Discuss the impact of age on cytochrome P450 enzyme activity.
Age can significantly alter CYP450 activity, with neonates often having reduced activity and
older adults experiencing changes in metabolism rates.
1
, What is the importance of understanding enzyme inducers in pharmacotherapy?
Understanding enzyme inducers helps predict drug interactions, as they can lead to decreased
efficacy of co-administered medications.
Describe how enzyme inhibitors affect drug concentrations in the body.
Enzyme inhibitors reduce the metabolic breakdown of drugs, leading to increased
concentrations and potential toxicity.
What are common clinical implications of using CYP450 inducers?
The use of CYP450 inducers can necessitate dose adjustments of medications that are
metabolized by those enzymes to maintain therapeutic effectiveness.
Explain the difference between competitive and non-competitive inhibition of CYP450 enzymes.
Competitive inhibition occurs when an inhibitor competes with a substrate for the enzyme's
active site, while non-competitive inhibition reduces the enzyme's activity regardless of substrate
presence.
What effect do dietary components have on cytochrome P450 enzymes?
Certain dietary components, like grapefruit juice, can inhibit specific CYP450 enzymes,
leading to altered drug metabolism.
How does the liver influence the cytochrome P450 system?
2
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