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MSN 611 Midterm Exam Study Guide with Complete Solutions Histamine that is not found within mast cells functions - Answer-as a neurotransmitter in the brain and is involved with neuroendocrine control, cardiovascular functions, thermal and weight regulation, and sleep and arousal balance what ...

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EMILLYCHARLOTTE 2024/2025 ACADEMIC YAER ©2024 EMILLYCHARLOTTE. ALL RIGHTS RESERVED
FIRST PUBLISH SEPTEMBER 2024




MSN 611 Midterm Exam Study Guide
with Complete Solutions

Histamine that is not found within mast cells functions - Answer✔✔-as a neurotransmitter in the brain

and is involved with neuroendocrine control, cardiovascular functions, thermal and weight regulation,

and sleep and arousal balance


what cells release histamine in the stomach? - Answer✔✔-enterochromaffin-like (ECL) cells


Toxicity of antihistamines has been reported in incidents of interactions with: - Answer✔✔-liver enzymes


Toxic effect of first-generation antihistamines - Answer✔✔-convulsions, postural hypotension, and

cardiac arrhythmias


Know anaphylaxis - Answer✔✔-


Central nervous system side effect of antihistamines in the elderly - Answer✔✔-BEERs list,


Indication H2 antihistamines - Answer✔✔-used to inhibit secretion of gastric cid with GI disorders


Know initial selection of antimicrobial therapy - Answer✔✔-


Mechanism of food-drug or drug-drug interactions with antibacterial medications - Answer✔✔-


Know multiple drug combination treatment for tuberculosis - Answer✔✔-isoniazid, rifampin,

pyrazinamide and ethambutol for up to 9 months




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,EMILLYCHARLOTTE 2024/2025 ACADEMIC YAER ©2024 EMILLYCHARLOTTE. ALL RIGHTS RESERVED
FIRST PUBLISH SEPTEMBER 2024


Know about description of IFN-β - Answer✔✔-(fibroblast interferon) IFNs are biological response

modifiers w an antiviral and immunolodulatory activity. IFN-B is released by human cells infected with

certain viruses- help create resistance to viral infections by acting on the host tissue cells


Type of pathogen causes malaria - Answer✔✔-plasmodium parasite?


Why systemic chemotherapy that is given prior to surgery or radiation is given - Answer✔✔-neoadjuvant

therapy is used to reduce the tumor burden and to increase the effectiveness of the local txt (126)


Tumor lysis syndrome management in leukemia patients - Answer✔✔-adequate IV hydration therapy, &

give allopurinol if hyperuricemia is anticipated (129)


Acrolein is a toxic metabolite of cyclophosphamide and ifosfamide that can cause what - Answer✔✔-

hemorrhagic cystitis (131)


Category of antineoplastic drugs offers an alternative when traditional treatments fail - Answer✔✔-

immunosuppressant antineoplastic agents may offer an alternative (137)


Topoisomerase inhibitors target enzymes that control changes in DNA - Answer✔✔-by altering the

phosphodiester structure of the strands during the normal life cycle of the cell


Effects of cholinesterase inhibitors have on the sinoatrial and atrioventricular nodes - Answer✔✔-they

have vagotonic effects on the SA and AV nodes, leading to bradycardia and AV block which may

exacerbate syncope or hypotensive events


Mechanism of action of "mixed acting" sympathomimetic drugs - Answer✔✔-may directly activate the

release of NE while also indirectly causing a release of NE (222)




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, EMILLYCHARLOTTE 2024/2025 ACADEMIC YAER ©2024 EMILLYCHARLOTTE. ALL RIGHTS RESERVED
FIRST PUBLISH SEPTEMBER 2024


Disease that GABA-derivative antispasmodic agents used effectively to control muscle spasm -

Answer✔✔-multiple sclerosis (227)


FDA-approved use for belladonna - Answer✔✔-for mod-severe pain associated with ureteral spasm

(bladder spasm) that is not responsive to non-narcotic analgesics


Interval for therapeutic effect of initial warfarin therapy - Answer✔✔-5-7 days after first dose


Function of plasmin - Answer✔✔-promotes hydrolysis of cross linked fibrin polymers


Derivation of antihemorrhagic agents - Answer✔✔-human sources- so monitor for infusion-related

reactions


Know anticoagulant therapy - Answer✔✔-p. 273


FDA-approved drug use in thrombocytopenia - Answer✔✔-anagrelide


Oprelvekin


Type of hypertensive medication should preferentially be considered for African Americans - Answer✔✔-

calcium-channel-blockers


Drug of choice for treating hypertension in pregnancy - Answer✔✔-methyldopa


Beta-blocker indicated for hypertensive emergencies - Answer✔✔-labetalol


Know renin-angiotensin-aldosterone inhibitors - Answer✔✔-Aliskiren


Therapeutic management of paroxysmal supraventricular tachycardia - Answer✔✔-flecainide


D2receptors are a drug development target for which disease? - Answer✔✔-parkinson's disease


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