BIOLOGY 2B03 - Cell Biology
Midterm 1 exam tips (possible
questions and answer) new update
McMaster University
, Problems in normal protein folding mechanisms lead to? - --fibril formation
Examples of 3 general problems in protein folding? - --1) mutation
2) old age
3) prion infection
examples of 4 more specific problems leading to fibril formation - --1) Genetic amyloid- related
diseases: single change in nucleotide lead to changed AA and unstable intermediates
2) Protein fragments do not fold into proper globular form
3) Breakdown of chaperone system
4) Infection by misfolded fibril structures
examples of prion-based diseases - --Mad Cow disease
Creutzfield-Jacob disease
Fatal Familial Insomnia
Hereditary diseases related to improper protein folding - --Alzheimer's disease
Tay-Sachs
Cystic Fibrosis
UPR in response to? - --Unfolded Protein Response; accumulation of misfolded proteins
Prolonged UPR =? - --Cell apoptosis (death)
Modes of prion acquisition? - --1) Spontaneous
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