DPR Exam 1 Review Study Guide with Complete Solutions
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Course
DPR
Institution
DPR
DPR Exam 1 Review Study Guide with
Complete Solutions
The Central Dogma states - Answer-Genes on DNA are translated to a protein
folded to there tertiary structure with chaperone proteins
The outward appearance of an organism, resulting from the genotype plus the
environment is referred to as ...
- in response to changes in voltage at the membrane
- in response to metabotropic reception activation
Voltage gated potassium channels are responsible for - Answer✔✔-repolarizing the
membrane during an action potential
Which ion is more concentrated on the intracellular side of the membrane? -
Answer✔✔-potassium
Describe the triplastic effect of SSRI when used to treat anxiety. Beside to describe the
receptor systems involved, and how they are related to anxiety in a general sense to
provide context for your answer. - Answer✔✔-SSRI's increase the amount of synaptic
5-HT available for binding on the the 5HT-1a receptors by blocking reuptake. Initially
this causes more anxiety as the SSRI acts on the 5HT receptors. These presynaptic
receptors form an inhibitory feedback loop. In the presence of increased 5HT, there is a
decrease in the firing rate of these serotanergic neurons. These cells ultimately correct
themselves tho, to eventually maintain their baseline firing rate. They achieve this by
eliminating the amount of receptors on the presynaptic cell. These then return to
baseline firing in conjunction with the increased amount of 5HT at the synapses and the
post-synaptic cells are now able to receive appropriate firing and 5HT, therefore
reducing overall anxiety. This nuerocellular process explains the delayed initial efficacy
of SSRI treatment of anxiety.
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