Exam (elaborations)
T cell activation, differentiation and memory questions and answers
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T cell activation, differentiation and memory
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1-28 of 281. TCR, CD3 and CD4 or CD8 with MHC peptide
-engagement of TCR
2. costimulation (not antigen specific)
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, T cell activation 2 signal hypothesis
-The interactions between a CD4 (left) or CD8 (right) T-cell and its
activating dendritic cell. a dendritic cell is APC. it present to ClassII
MHC or it can load internal peptides into MHC classI.
-CD28 interactions with CD80/86 provide the require costimulatory
signals. adhesion molecules (LFA-1/ICAM, LFA3/CD2) strengthen
connection between the T cell and APC or target cell so that signals
can be sustained.
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surface interactions responsible for T cell activation
-skin and intestines: more resident memory T cells
-no resident T cells in blood- need circulating T cells in blood. usually you will central
memory T cells in blood and secondary lymph organs
-T cells have many markers which determines its identity. each memory cell has it own
marker profile which is used to compartmentalize cells. ex: CD45 is only found in
Stem cell memory T cells. then theres also CD103 which is an epithelial binding
antigen only found on Trm. early activation marker CD69 is also only found on Trm.
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why would you see certain T cells in certain places?
-in the case of hyperactivity, CTLA-4 binding domain is used. it is soluble and looks
like IgG but can bind to CTLA4.
-APCs have B7 which you want to block CD28 binding from. in this case, CTLA4-Ig is
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