Summary
Summary - HTHSCI 3I03|HTHSCI 3I03 - Midterm 1 Notes
- Course
- Institution
HTHSCI 3I03 - Midterm 1 Notes
[Show more]
Content preview
1-137 of 137Necrosis
Give this one a go later!
, - Not immunogenic
- Mass cell death of a specific tissue or organ
- inflammatory cell death
- DAMPs released
- inflammation cascade signaled
What are the results of the complement system?
Give this one a go later!
- C3a recruits lots of inflammatory signals
- C3b acts as an opsonin to trigger phagocytosis of pathogen
- C3b causes formation of membrane attack complex (MAC) which
perforates cell membrane
- DEATH OF PATHOGEN
What are the 4 components of innate immunity?
Give this one a go later!
1) Macrophages
2) Neutrophils
3) Eosinophils
4) Natural Killer cells
What is an antigen presenting cell in the context of MHC Class 1? Class 2?
Give this one a go later!
, - Any nucleated cells express MHC class 1
- Professional APC only for class 2 (Ex. dendritic cell)
What is Necroptosis?
Give this one a go later!
- inflammatory cell death
- DAMPs released
What are the two functions of innate immune cells under the skin and mucosal
surfaces?
Give this one a go later!
1) Immediately capture and kill invading pathogen
2) recognize pathogen and lead to induced immune system
What are the three types of NK cells?
Give this one a go later!
1) killer (cytotoxic)
2) healer (tissue remodeling)
- help remodel blood vessels to baby during pregnancy
3) IFN-gamma producing
, What is the antimicrobial relevance of keratinized upper cell layer?
Give this one a go later!
- VIRUSES require receptors to infect and fusion with a LIVE host!
- this property DOES NOT apply to bacteria!
Why do NK cells not kill RBCs?
Give this one a go later!
- no MHC so do not produce any inhibitory signal BUT
- do not produce any activating signal either unless infected
What is HLA? What are three human Class 1 MHC and 3 human class 2 MHC?
What is special about class 2 (affects naming)
Give this one a go later!
Human Leukocyte Agent
Class 1: HLA-A, -B, -C
Class 2: HLA-DR, -DP, -DQ
Class 2 is coded by 2 genes since it has 2 polypeptides
What happens if you lack innate vs adaptive immunity?
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller codersimon. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.00. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
75759 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now