Any infectious organism that enters the body will be eliminated by the immune
response
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Non-infectious self and infectious non-self hypothesis
, Ligand: profilin and profilin-like proteins (Toxoplasma gondii and uropathogenic
bacteria)
Cellular distribution: macrophages, dendritic cells, liver, kidney, and bladder epithelial
cells
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TLR-11 (mouse only)
Mannose and fucose residues with correct spacing
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What does MBL bind to?
Those that recognize microbial DNA and RNA: 8, 9, 7, 3
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Endosomal TLRs
- 2-6 clusters of carbohydrate-recognition domains
- Carbohydrate binding sites within each cluster have a fixed orientation
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