3 main goals of treatment: - answer✔Cure
Control
Palliation
Define neoadjuvant therapy - answer✔Treatment is given prior to surgery to shrink the tumor
Define adjuvant therapy - answer✔Additional cancer treatment given after the primary treatment
to lower the risk that the cancer reoccur
Define conditioning/preparative therapy - answer✔Treatments used to prepare a patient for stem
cell transplantation
2 types of conditioning therapies: - answer✔Myeloablative
Nonmyeloablative
Define dose density - answer✔Drug dose per unit of time
Define dose intensity - answer✔Amount of drug delivered over time
How is relative dose intensity (RDI) calculated? - answer✔By comparing the dose that the
patient ACTUALLY received to the planned dose of the standard regimen
How do alkylating agents work? - answer✔By causing a break in the DNA helix strand,
interfering with DNA replication and causing cell death
3 subcategories of alkylating agents: - answer✔1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating agents as they
work similarly)
3. Nitrosoureas
Most common subcategory of alkylating agents: - answer✔Nitrogen mustards
Common alkylating agents: - answer✔Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
Common platinum-based agents: - answer✔Cisplatin (Platinol)
Carboplatin (Paraplatin)
What is unique about nitrosoureas agents? - answer✔Able to cross the blood-brain barrier; can
be effective in treating some brain tumors
Common nitrosoureas agents: - answer✔Carmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
Hypersensitivity can occur with late doses of: - answer✔Carboplatin
These agents are typically categorized as highly emetogenic: - answer✔1. Alkylating agents
2. Nitrosoureas
Pre-administration labs for alkylating agents and nitrosoureas: - answer✔BUN
Creatinine
CBC w/ diff
What is the medication Mesna used for? - answer✔Bladder protectant with administration of
cyclophosphamide or ifosfamide
Instruct pts receiving ________ to avoid exposure to cold air and consuming cold fluids for 3-4
days following treatment - answer✔Oxaliplatin
How do antimetabolites function? - answer✔By blocking DNA and RNA growth by interfering
with enzymes needed for normal cell metabolism
Antimetabolites work in the ___ phase. - answer✔S
What types of cells are best affected by antimetabolites? - answer✔Cells with high division rates
Common side effects of antimetabolites: - answer✔Myelosuppression
GI toxicities
Photosensitivity
Hand-foot syndrome
Common antimetabolite drugs: - answer✔Azacitidine
Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Brainbarter. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.49. You're not tied to anything after your purchase.
