NR546 ADVANCED PHARMACOLOGY:
PSYCHOPHARMACOLOGY FOR PSYCHIATRIC-MENTAL
HEALTH NURSE PRACTITIONER ACTUAL EXAM
COMPLETE 250 QUESTIONS AND CORRECT DETAILED
ANSWERS (VERIFIED ANSWERS) |ALREADY GRADED
A+||BRAND NEW!!.
Week 1✔✔ ANSWER✔✔
The imbalance of dopamine (DA) and acetylcholine (ACh) can result in
anticholinergic effects such as?✔✔ ANSWER✔✔Dry mouth, blurred vision,
racing heart, constipation, and drowsiness due to muscarinic blockade.
Histamine blockade✔✔ ANSWER✔✔Weight gain and drowsiness
α1-adrenergic blockade✔✔ ANSWER✔✔Orthostatic hypotension, dizziness,
and drowsiness
Chlorpromazine
FGA: Chlorpromazine
Potency: Low
Additional Indications & Considerations: 2nd line due to QTc issues✔✔
ANSWER✔✔
Mesoridazine
,FGA: Mesoridazine
Potency: Low✔✔ ANSWER✔✔
Thioridazine
FGA: Thioridazine
Potency: Low
Additional Indications & Considerations: 2nd line due to QTc issues✔✔
ANSWER✔✔
Haloperidol
FGA: Haloperidol
Potency: High
Additional Indications & Considerations: Appropriate for acute, severe
agitation and aggression✔✔ ANSWER✔✔
,Negative symptoms are more difficult to treat successfully than positive
symptoms. True or False✔✔ ANSWER✔✔True
SGAs are considered serotonin-dopamine antagonists✔✔ ANSWER✔✔
The imbalance between acetylcholine (ACh) and dopamine (DA),
characteristic in FGAs, is less prominent in SGAs✔✔ ANSWER✔✔
Due to the antagonism of serotonin, SGAs generally have fewer EPS and
prolactin effects than FGAs making them the first-line choice when
prescribing medications for schizophrenia.✔✔ ANSWER✔✔
SGAs are classified by pharmacological properties related to their binding
capacity.✔✔ ANSWER✔✔The potency of binding is responsible for
medication efficacy and side effects.
An easy way to remember SGA categories? (Phrase)✔✔ ANSWER✔✔"the -
pines (peens), many dones and a rone , two pips and a rip
SGA Pines✔✔ ANSWER✔✔Bind more potently to the 5HT 2A receptor than
the D2. Sedation is common (high affinity for histamine).
Least risk of EPS but a high risk for weight gain and metabolic abnormalities.
Olanzapine (Zyprexa) (Pine)✔✔ ANSWER✔✔FDA approved for treatment of
schizophrenia age 13 and older
, Best tolerated antipsychotic
High metabolic risk
Highest risk for weight gain, blood dyscrasias, QT prolongation,
cardiovascular disease, cerebrovascular effects, hyperglycemia, and
hyperprolactinemia
Quetiapine (Seroquel) (Pine)✔✔ ANSWER✔✔For schizophrenia ages 13 and
older
Moderate metabolic risk
Low EPS risk
Risk of orthostatic hypotension, blood dyscrasias (neutropenia, leukopenia,
and agranulocytosis), QT prolongation, weight gain, and renal and hepatic
impairment
Asenapine (Saphris) (Pine)✔✔ ANSWER✔✔FDA approved for schizophrenia
ages 10 and older
Available in sublingual and transdermal patch
Low metabolic risk
Clozapine (Clozaril) (Pine)✔✔ ANSWER✔✔For treatment-resistant
schizophrenia and chronic suicidal behavior in schizophrenia or
schizoaffective disorder
Not indicated in acute presentation of schizophrenia
The Absolute Neutrophil Count (ANC) must be >1500/mm3 when used and
requires initial and weekly monitoring of WBC, granulocyte, and neutrophil
counts.
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