name given to them by the company who created the druh
brand name
commercial name, capitalized
what are the different types of oral medications?
liquid, tablet, capsule, powder
which form absorbs the fastest?
liquid
which form absorbs the slowest?
enteric coated tablet
what are the 3 ways a drug can be delivered parenterally?
intravenously, subcutaneously, intramuscularly
which parenteral drug is fastest?
IV
Slowest route of administration
transdermal
pharmacokinetics
movement of drugs from site of administration to various tissues
1st pass effect
some of the drugs when passed though the liver may deactivate —> reduces effect of
drugs
bioavailability
amount of oral drug after passing through the liver
, parenteral drugs
does not get affected by 1st pass effect because it goes directly to the vein or tissue
what factors affect distribution to different parts of the body?
-movement of drug by circulatory system to intended site of action
-drugs enter the blood after they absorb through intestinal wall or alveoli in lungs or
after direct/indirect injection
-liver, heart, kidneys receive most of drugs because of their rich drug supply
-bones or areas with natural barrier-brain-won't receive as much of the drug
Metabolism (biotransformation)
biochemical alteration of a drug into an inactive metabolite, a more soluble compound a
more potent active metabolite or a less active metabolite
biotransformation
when drug is chemically changed during excretion Where does metabolism take place?
liver
half life
quantity of time it takes for a medication that enters the body to be broken down by half
What must be considered with regards to medication levels in the body if a patient has
diminished liver and /or kidney function?
Dosage may need to be reduced/re-evaluated depending on quantity of the medication
that will be in the system
onset
the time the drug takes to produce a therapeutic effect
peak
The length of time it takes for a medication to have its maximum therapeutic effect
duration
length of time the medication is effective without additional dosing
trough level
The amount of drug in the body that is lowest after the peak level has been achieved The
blood sample drawn to check therapeutic levels of a medication.
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