PHCY 402 BMS Exam II Questions With Correct Answers
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Course
Phcy 402
Institution
Phcy 402
PHCY 402 BMS Exam II Questions With
Correct Answers
Vancomycin (Vancocin, Vancoled) - answer- IV/PO glycopeptide
- gm (+) ONLY; too polar for gm (-) outer membrane & too large for porin channels
- MOA: inhibits polymerization of transglycosylase by binding to the D-ala-D terminus (+
inhibits s...
PHCY 402 BMS Exam II Questions With
Correct Answers
Vancomycin (Vancocin, Vancoled) - answer✔- IV/PO glycopeptide
- gm (+) ONLY; too polar for gm (-) outer membrane & too large for porin channels
- MOA: inhibits polymerization of transglycosylase by binding to the D-ala-D terminus (+
inhibits some protein synthesis)
- SE: nephro & ototox, **red-man syndrome: give slowly over 1-2+ hrs alongside antihistamines
to avoid
Telavancin (Vibativ) - answer✔- IV lipoglycopeptide
-Tx: gm (+) skin infections
- lipophilic side chain increases binding to lipophilic membrane
- SE: red man, nephrotox, teratogenic, increased QT, interferes w clotting tests
Oritavancin Phosphate (Orbactiv) - answer✔- glycopeptide or lipoglycopeptide
-IV, long half life, good for outpatient treatment.
- Tx: gm- MRSA complicated skin and skin structure infections
- SE: Heparin CI w/in 48 hrs, clotting tests become falsely positive
Dalbavancin HCl (dalvance) - answer✔- IV glycopeptide/lipoglycopeptide
-long half life, good for outpatient treatment
Tx: gm +, MRSA complicated skin and skin structure infections, resistant strep and
enterococcus.
SE: no redman syndrome; regular N&V
Bacitracin (Neosporin, Polysporin) - answer✔- IM/topical polypeptide
- Tx: gm (+) staph aureus/epidermidis, strep pyogenes; skin surface infections, sterilization of
wounds; IM last resort high resistant GM (+)
- OTC products add polymyxin B/neomycin for gm (-) activity
Polymyxcin B - answer✔- cationic polypeptide detergent
- DAB similar to Lys positively charged @ physiological pH
-MOA: binds to neg charged phospholipids in gm (-) cell
- Tx: severe hospitalized/resistant Pseud infections
Colistimethate (Coly-Mycin M) - answer✔- IV/IM/inhalation polypeptide prodrug
- Tx: some MDR-KES, pen-ceph resistant MDR pseud, aminoglycoside resistant pseud;
inhalation for CF
- SE: nephrotox, neurotox, muscle relaxer DI
Streptomycin - answer✔- aminoglycoside
- guanidino: forms delocalized cation when protonated
- Tx: TB (combo w isoniazid, ethambutol, rifampin), yersinea pestis, francisella tulariensis
- Tox: oto (vestibulo: tinnitus, vertigo/chochleo: high frequency hearingg)
Gentamicin (Garamycin) - answer✔- IV/IM aminoglycoside
- a lot of the same Tx & tox as streptomycin, more toxic & potent however
Tobramycin (Nebcin) - answer✔- IV/IM aminoglycoside
- Tx UTI, nebulizer for Pseud RTI, CF
-monitor for ototox
Kanamycin (Kantrex) - answer✔- IV/IM/PO aminglycoside (mostly PO)
- Tx: KES, no pseudo activity, 2nd line hepatic coma
Amikacin (Amikin) - answer✔- IV/IM aminoglycoside
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