Serotonin Syndrome causes - Answer: What classes can increase serotonin levels
-SSRI/SRNI/TCA/MAOI .....
----don't give more than 1 drug in each class at any time
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,----when switching from one class to another, wait 2 weeks for drug to degenerate
(completely clear from body)
---when switching ssri to a maoi wait 2 weeks
----when switching fluoxetine (prozac) to MAOI wait 5-6 weeks
-----when switching MAOI to fluoxetine wait 2 weeks
Washout period of 5 half lives between cessation of previous drug and
introduction of new drug is the safest strategy to avoid drug interactions
Triptans for migraines (i.e. Sumatriptan) increase serotonin levels, thus cannot be
taken with SSRI/SRNI/TCA/MAOI = Serotonin Syndrome
-----give NDRI
St John Wort increase serotonin levels, thus cannot be taken with
SSRI/SRNI/TCA/MAOI = Serotonin Syndrome
What disorders increase thoughts of self harm... - Answer: -Depression, bipolar,
ETOH abuse, eating disorder, & schizophrenia
Serotonin Syndrome - Answer: -caused by antidepressants
S/E
-hyperreflexia
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, -myoclonic jerks
Tx: D/C offending agent
-Cyproheptadine
SSRIs is safe for.... - Answer: -Ist line Tx for depression d/t low risk of overdose
-has fewer drug-drug interaction-- safe for Cancer pt.
Use: depression, GAD, panic disorder, OCD, bulimia, social phobias, and PTSD
SE: GI distress, SIADH (body retains too much H2O, SEXUAL DYSFUNCTION
If pt complains of sexual dysfunction- give wellbutrin (NDRI)
Takes 4-8 weeks to kick in
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