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CPJE TOP 400 DRUGS & DOSES
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CPJE TOP 400 DRUGS & DOSES
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CPJE TOP 400 DRUGS & DOSESTylenol - Answers -Acetaminophen
I: fever/pain
D: 325-650mg, max < 4000mg/day from all sources
*OD = liver damage, use NAC for antidote
Ofirmev (IV) - Answers -Acetaminophen
I: fever/pain
D: < 4000mg/day from all sources
*Can treat more severe pain
*OD = liver damage, use NAC for antidote
NAC - Answers -N-acetylcysteine
I: APAP overdose
Daypro - Answers -Oxaprozin
I: fever/pain/inflammation
*Similar caution to piroxicam: high risk for GI tox and severe SJS
*BBW: COX-1 selectivity NSAID = GI bleed
Voltaren - Answers -Diclofenac (gel)
I: pain/inflammation
Dose: AAA 2-4g QID
Toradol - Answers -Ketorolac
I: analgesia
D:
-IV/IM 30mg x 1, or 30mg QID (max 120mg/d)
-PO: 20mg once after IV or IM, then 10mg q4-6hr (max: 40mg/d)
*Max = 5 days of treatment
*Most GI toxic w/ piroxicam
*BBW: COX-1 selectivity NSAID = GI bleed
Indocin - Answers -Indomethacin
-I: fever/pain/inflammation, gout
-D: 25-50mg IR, 75mg BID CR
*High risk for CNS SE and GI toxicity
*BBW: COX-1 selectivity NSAID = GI bleed
Clinoril - Answers -Sulindac
*less common NSAID that may be better w/ reduced renal function
*BBW: COX-1 selectivity NSAID = GI bleed
Relafen - Answers -Nabumetone
I: fever/pain/inflammation
,D: 1000-200mg qd or bid
Feldene - Answers -Piroxicam
I: fever/pain/inflammation
D: 10-20mg qd
*High risk for GI tox and severe SJS
*Most GI toxic w/ ketorolac
*BBW: COX-1 selectivity NSAID = GI bleed
Mobic - Answers -Meloxicam
I: fever/pain/inflammation
D: 7.5-15mg po (Max: 15mg/d)
*COX-2 selectivity NSAID: CV event (MI, stroke)
Bayer - Answers -Aspirin
I: fever/pain/inflammation
D: 81-325mg qd
CI: pregnancy (esp 3rd trimester), OD = tinnitis
*BBW: COX-1 selectivity NSAID = GI bleed
Motrin, Advil - Answers -Ibuprofen
I: fever/pain/inflammation
Dose
-OTC: 200-400mg q 4-6 hrs
-Rx: 600-800 mg tid, max 3200mg/d
*BBW: COX-1 selectivity NSAID = GI bleed
Naprosyn - Answers -Naproxen, Aleve
I: fever/pain/inflammation
D:
-OTC: 220mg qd
-Rx: 250-550mg bid
*Higher GI side effects
*BBW: COX-1 selectivity NSAID = GI bleed
Celebrex - Answers -Celecoxib
I: fever/pain/inflammation
D: 200mg qd or BID
*lowest GI bleed risk but highest CV risk
*COX-2 selectivity NSAID: CV event (MI, stroke)
Humira - Answers -Adalimumab
I: arthritis, psoriasis, Crohn's, UC, etc
D: 40mg SC every other week
*BBW: fatal infections, malignancy, TB
,Remicade - Answers -Infliximab
I: arthritis, psoriasis, Crohn's, UC, etc
D: 3 mg/kg IV on weeks 0, 2 and 6, then q8w
*Delayed hypersensitivity reactions
*BBW: fatal infections, malignancy, TB
Enbrel - Answers -Etanercept
I: arthritis, psoriasis, Crohn's, UC, etc
D: 50mg SC weekly
*BBW: fatal infections, malignancy, TB
Orencia - Answers -Abatacept
I: arthritis
D: 500-1000mg IV at 0, 2 and 4 weeks, then qm, 125mg SC weekly
*NS only
*Warnings: malignancies, serious infections, may worsen COPD sx
Kineret - Answers -Anakinra
I: RA
D: 100mg SC qd
*Warnings: malignancies, serious infections
Arava - Answers -Leflunomide
I: DMARD
D: 100mg PO x 3d, then 20mg PO qd
*BBW: embryo-fetal toxicity, hepatotoxicity
*CI: pregnancy (must have negative preg test and 2 forms of birth control & wait 2 yrs
after DC to have kids)
Azulfidine - Answers -Sulfasalazine
I: DMARD
D: 500-1000mg qd, then 1000mg BID
*CI: sulfa allergy
Rheumatrex - Answers -Methotrexate
I: DMARD
D: 7.5-20mg once weekly (never daily for RA)
*BBW: hepatotoxicty, myelosuppression, mucosititis/stomatitis
Plaquenil - Answers -Hydroxychloroquine
I: DMARD
D: 400mg qd, then 300mg qd
*Warnings: irreversible retinopathy
Imuran - Answers -Azathioprine
I: RA, transplant
, D: 1.5-3mg/kg/d IV or PO
*BBW: increased risk of malignancy in IBD
*Warning: hematologic toxicity, increased risk of myelosuppression in TPMT pts
Veetids - Answers -Penicillin VK
I: infection
D: hella
*Renal toxicity
Dynapen - Answers -Dicloxacillin
I: staph infection
D: 125-500mg q6h PO
Unasyn - Answers -Ampicillin/sulbactam
D: 1.5-3 g q6h
*NS only
Principen - Answers -Ampicillin
D: 250-500mg po q6h, 1-2g IV q4-6h
*Empty stomach
*NS only
Amoxil, Moxatag - Answers -Amoxicillin
D: 250-500mg q8-12h,
500-875 q12h
*Take w/ food
Augmentin - Answers -Amoxicillin/clavulanic
D: 875/125mg po q12hr
*Take w/ food
Zosyn - Answers -Piperacillin/tazobactam
D:
-3.375 g QID IV
-4.5 TID-QID
-3.375-4.5g IV TID (each dose infused over 4 hrs)
Ancef - Answers -Cefazolin
1-2g q8hr IV/IM
*1st gen
Ancef, Kefzol - Answers -Cefazolin
1-2g q8hr IV/IM
*1st gen
Keflex - Answers -Cephalexin
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