Can Empagliflozin be taken with Furosemide? Explain. -
ANSWER- Empagliflozin increases renal excretion of glucose
in the urine. This can lead to diuretic effect and as a result would
interact poorly with Furosemide leading to dehydration
Canagliflozin and Lisinopril can be taken together with no
interactions, True or False? - ANSWER- False
What is the MOA of sulfonylureas? - ANSWER- Sulfonylureas
bind to sulfonylurea receptors (SUR1), which is a component of
ATP-sensitive K channel. Binding of SU to SUR closes the
KATP channel and result in Ca2+ influx and insulin release.
,2|Page
Which Sulfonylurea has the highest risk of Liver Toxicity? -
ANSWER- Glipizide
Which Sulfonylurea has the highest risk of Renal Toxicity? -
ANSWER- Glyburide
Which Sulfonylurea has the highest risk of Liver and Renal
Toxicity? - ANSWER- Glimepiride
What type of cells do Sulfonyureas work on? - ANSWER-
Pancreatic Beta cells
What is the difference between Glupizide and Repaglinide? -
ANSWER- These two medications have the same MOA and are
both taken orally. But Repaglinide is more rapid acting and has a
shorter duration
Which of these medications are best for controlling
POSTPRANDIAL glucose production? (SATA)
A. Acarbose
B. Nateglinide
C. Glimepiride
, 3|Page
D. Miglitol - ANSWER- A. Acarbose
B. Nateglinide
D. Miglitol
What is the MOA of Semaglutide? - ANSWER- The medication
binds to activate GLP-1 Receptor on pancreatic beta cells,
enhancing glucose depends insulin secretion.
Reduces glucagon secretion
Slows gastric emptying
What are the side effects of GLP-1 receptor agonist? (8) -
ANSWER- GI Disturbances
Decrease appetite
Weight loss
Fatigue
Hypoglycemia
Risk for acute pancreatitis
Increase Risk for Medullary Thyroid Cancer
Name the GLP-1 agonists (6) - ANSWER- Exenatide
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