Nonalcoholic Fatty Liver Disease- caused by obesity, hyperglycemia, elevated serum lipids,
and high BP
Non-alcoholic steatohepatitis. can lead to cirrhosis 3rd common indication for liver tx.
Methylprednisolone (solu-medrol), or IV or Oral prednisone
Immediate return to or for revascularization of organ
Term 2 of 46
Risk of primary non-function after liver transplant is:
1-2%
4-6%
10-12%
35-40%
,Term 3 of 46
Why are induction agents given pre- or intraoperatively in transplant?
Increase in LFTs due to decreased blood flow through the hapatic artery to new organ
Delayed bile leak
Persistent sepsis of unknown cause
decrease in bile production
extreme edema of organ
Abnormal color of organ upon reperfusion(mottled, gray, pale)
lack of reperfusion in OR
urine output <30ml/hr
hemodynamically unstable
glucose, k, and lactate abnormalities
Coagulopathy
Decrease incidence of acute rejection
delay first rejection
delay use of calcineurin inhibitors due to their nephrotixicity
Electrolyte imbalances, reaction to cyclosporine or tacrolimus, intracranial hemorrhage or
cerebral infarction and intracerebral abscesses
Term 4 of 46
Target levels for immunosuppressants are based on a number of factors including:
Indication for tx, use of induction therapy, kidney function, overall condition of pt.
Weather conditions in the area
Number of siblings the patient has
Patient's favorite color
, Definition 5 of 46
Fever and chills shortly after infusion
DM, HTN, high cholesterol, weight gain, fluid retention, indigestion, bone loss(long term
use),
Hypoglycemia, hypotension, normal cholesterol, muscle gain, bloating, acid reflux, bone
density increase
Fatigue, high blood pressure, elevated cholesterol, muscle loss, water retention, stomach
ache, bone fractures
Definition 7 of 46
Tacrolimus(prograf)
Cyclosporine(neoral or gengraf)
Corticosteroids
Mtor inhibitors
Calcineurin inhibitors
Antiproliferative agents
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