UNE BIOCHEM 1005 FINAL EXAM WITH VERIFIED ANSWERS GRADED A+
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UNE BIOCHEM 1005
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UNE BIOCHEM 1005
UNE BIOCHEM 1005 FINAL EXAM WITH VERIFIED ANSWERS
GRADED A+
1. c. Somatostatin
activates an in-
hibitory G-pro-
tein
2. a. Translocation
of GLUT 4 recep-
tors to the cell
surface
3. a. To move
ammonia from
skeletal muscle
to the liver
4. a. Protein ki-
nase A mediat-
ed phosphoryla-...
UNE BIOCHEM 1005 FINAL EXAM WITH VERIFIED ANSWERS
GRADED A+
1. c. Somatostatin Somatostatin reduces the secretion of both glucagon and
activates an in- insulin through which of the following mechanisms?
hibitory G-pro-
tein a. Somatostatin activates an activator G-protein
b. Somatostatin activates MAPK cascade
c. Somatostatin activates an inhibitory G-protein
d. Somatostatin uses Ca+2 as a downstream signal
2. a. Translocation Insulin mediated glucose uptake by muscle and adipose
of GLUT 4 recep- tissue is a result of which of the following mechanisms?
tors to the cell
surface a. Translocation of GLUT 4 receptors to the cell surface
b. Translocation of GLUT 1 (Na+/K+ symporter) to the cell
surface
c. Passive diffusion
d. Activation of protein kinase A
3. a. To move The alanine - glucose cycle is primarily used for which of
ammonia from the following purposes?
skeletal muscle
to the liver a. To move ammonia from skeletal muscle to the liver
b. To generate ATP for the skeletal muscle
c. To move glucose from the skeletal muscle to the liver
d. To move alanine from the liver to the skeletal muscle
4. a. Protein ki- Which statement best illustrates an example of post trans-
nase A mediat- lational gene regulation?
ed phosphoryla-
tion of glycogen a. Protein kinase A mediated phosphorylation of glycogen
phosphorylase phosphorylase
b. Cortisol binds a cytosolic receptor, translocates to the
nucleus and binds a GRE
c. Iron binding the iron response elements binding protein
(IRE_BP) allowing for translation of ferritin mRNA
d. DNA histone associations leading to super-coiling of
DNA
5. Which of the following hormones is released from the liver
in response to increased levels of growth hormone?
, UNE BIOCHEM 1005 FINAL EXAM WITH VERIFIED ANSWERS
GRADED A+
d. Insulin-like
growth factor a. Cortisol
(IGF) b. Thyroid hormone
c. Somatostatin
d. Insulin-like growth factor (IGF)
6. c. mTOR is acti- Autophagy is process involves degradation of protein. Un-
vated der conditions of high energy (HIGH ATP) which of the
following is true regarding regulation of this process?
a. Akt is inactive
b. AMPK is actice and phosphorylates TSC1/TSC2 Com-
plex
c. mTOR is activated
d. Rheb is bound to GDP
7. d. VLDL Synthesis of which of the following lipoproteins would be
elevated after a carbohydrate rich meal?
a. HDL
b. Chylomicrons
c. LDL
d. VLDL
8. b. Carbamoyl The synthesis of N-acetylglutamate (NAGS) is required for
phosphate syn- the activity of the urea cycle. This compound stimulates
thetase I (CPSI) the activity of which of the following enzymes?
a. Arginase
b. Carbamoyl phosphate synthetase I (CPSI)
c. Ornithine transcarbamoylase
d. Carbamoyl phosphate synthetase II (CPSII)
9. b. Decreased lev- A male infant starts to show signs of lethargy rapidly
els of carbamoyl after birth. Upon evaluation he is determined to have a
phosphate deficiency in n-acetylglutamate synthesis. Based on this
information, which of the following would consistent with
this diagnosis?
a. Elevated levels of arginine
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