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NAPLEX PRACTICE QUESTIONS AND ANSWERS
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NAPLEX PRACTICE QUESTIONS AND ANSWERS
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NAPLEX REVIEW QUESTIONS ANDANSWERS
Whattistthetequationtfortcorrectedtphenytoin?t-tans✔✔CP=tmeasuredtserumtphenytoin/
(0.2*albumin)+0.1
Whattistthetprincipletintracellulartcation?t-tans✔✔potassium
PrincipletextracellulartistSodium
HowtmanytmLtintatteaspoon?t-tans✔✔5tmL
howtmanytmLtintattablespoont-tans✔✔15tmL
howtmanytmLtintatcup?t-tans✔✔240tmL
howtmanytmLtintantounce?t-tans✔✔29.6tmL
howtmanytmLtintatpint?t-tans✔✔473tmL
howtmanytmLtintatgallon?t-tans✔✔3785tmL
Howtdotwetcalculatetmolstortmmolstoftatsubstance?t-tans✔✔mol=tg/MW
mmol=tmg/MW
Howtmanytmgtaretintonetgrain?t-tans✔✔65tmg/grain
Howtmanytlbstintatkg?t-tans✔✔2.2lbs/kg
Whattistthetconversiontoftaminophyllinettottheophylline?t-
tans✔✔wetmultiplytthetaminophyllinetbyt0.8ttotgettthetequivalentttheophylline
Whattistthetconversiontofttheophyllinettotaminophylline?t-
tans✔✔dividetthetamounttofttheophyllinetbyt0.8ttotgettthetequivalenttaminophylline
Howtdotwetgettthetratiotstrengthtfromtthetpercenttstrength?t-
tans✔✔ratiotstrength=t100/%tstrength
,Howtdotwetgettthetpercenttstrengthtfromtthetratiotstrength?t-tans✔✔%tstrength=t100/
ratiotstrength
HowtdotwetconverttPPMttotpercenttstrength?t-tans✔✔-PPMttot
%tstrength,tmovetdecimaltleftt4tplaces
-%tstrengthttotPPM,tmovetdecimaltplacetrightt4tplaces
specifictgravityt-tans✔✔SG=tgramstoftsubstance/mL
mEqt-tans✔✔mEq=tmgtxtvalence/MW
Whichtchemicalsthavet2tvalences?t-tans✔✔Calciumtcarbonate
Calciumtchloride
Ferroustsulfate
Magnesiumtsulfate
mOsmol/Lt-tans✔✔mOsmol/L=t[wttoftsubstancet(g/L)/MWt(g/
mole)]txtnumbertoftparticlestxt1000
Equationtfortaniontgap`t-tans✔✔Nat-t(Clt+tBicarbonate)
Howtmuchtelementaltcalciumtistfoundtintcalciumtcarbonatetandtcalciumtcitrate?t-
tans✔✔40%tintcarbonate
20%tintcitrate
HowtmuchtelementaltIrontistintferroustfumarate,tferroustsulfate,tandtferroustgluconate?t-
tans✔✔fumarate:t108tmg
sulfate:t65tmgtoft325mgt(20%)
gluconatet35tmg
Howtistabsolutetneutrophiltcounttcalculated?t-tans✔✔ANC=tWBCtxt[(%segst+t%bands)/
100]
Whattistthetformulattotdeterminetatpatient'sttotaltenergytexpenditure?t-
tans✔✔TEE=tBEEtxtactivitytfactortXtstresstfactor
WhattistthetequationttotfindtpHtoftatweaktacid?t-tans✔✔pHt=tpKat+tlog(salt/acid)
WhattistthetequationttotfindtpHtoftatweaktbase?t-tans✔✔pHt=t(pKwt-tpKb)t+tlog(base/salt)
whattcantwettelltabouttionizationtoftacidstfromtthetpHtandtthetpKa?t-
tans✔✔pHt>tpKatmoretacidtistionized
pHt=tpKationizedtandtunionizedtaretequal
pHt<tpKatmoretacidtistunionized
,Antionizedtdrugtistmoretsolubletbuttcannotteasilytcrosstlipidtmembranestandtvicetversa
HowtaretthetABGtmeasurementstwrittentouttontthetexam?t-tans✔✔pH/pCO2/pO2/HCO3/
O2
WhattaretthetnormaltvaluestfortpH,tHCO3,tandtpCO2?t-tans✔✔pHt=t7.35-7.45
HCO3t=t38-42
pCO2t=t22-28
WhentaddingtcalciumtandtphosphatettotTPNtwhattshouldtbetconsidered?t-tans✔✔-
Usetcalciumtgluconatetovertcalciumtchloridetbecausetittistlesstreactivetandtatlowertratetoftpr
ecipitation.
-Addtphosphatetfirsttthentaddtcalciumtattthetendtoftthetprept
-whentaddedttogethertdon'ttexceedt45tmEq/L
BMIt-tans✔✔weighttintkg/heighttintmeter^2
BSAt-tans✔✔BSAt=tSQRt[weight(kg)txtheightt(cm)/3600]
Howtmanytkcalstaretint10%,t20%,tandt30%tintravenoustfattemulsions?
tHowtmuchtfattistneededtfortTPN?t-tans✔✔10%t=t1.1tkcal/mL
20%t=t2tkcal/mL
30%t=t3tkcal/mL
FattfortTPNt=t9tkcal/gram
HowtmanytkcalstdotaminotacidstandtdextrosetprovidetintTPN?t-tans✔✔Aminotacidst4tkcal/
gram
dextroset3.4tkcal/gram
whattistthetpKa?t-
tans✔✔ThetpKatistthetpHtattwhichthalftthetdrugtist50%tionized.tThististhalftthetneutralizationt
ortequivalencetpoint.tThetneutralizationtortequivalencetpointtistattatmuchthighertpHtandtoccu
rstwhentthetacidthastbeentneutralized.
whattistthetcorrecttcalciumtequation?t-tans✔✔CorrectedtCat=t[(4.0-
albumin)txt0.8]t+tserumtcalcium
Whattistthetequationtfortabsolutetbioavailability?t-tans✔✔F=t100txt(AUCtextravascular/
AUCtintravascular)txt(Dosetintravascular/Dosetextravascular)
Whattistthetequationttotfindtthetvolumetoftdistribution?t-tans✔✔Vdt=tamounttoftdrugtgiven/
concentrationtoftdrugtintplasma
Whattistthetequationtfortclearance?t-tans✔✔Clt=tratetoftelimination/concentration
Clt=tFtxtDose/AUC
, Clt=tDose/AUCt(iftbioavailabilitytist1)
whattistthetequationtforttheteliminationtratetconstant?t-tans✔✔ket=tClearance/
volumetoftdistribution
Howtdotwetfindtthethalf-life?t-tans✔✔t1/2t=t0.693/ke
Howtdotwetdefinetpharmacodynamicstvs.tpharmacokinetics?t-
tans✔✔pharmacodynamics: twhattthetdrugtdoesttotthetbody
Pharmacokinetics:twhattthetbodytdoesttotthetdrug
FormulattotdeterminetpatientstLDLt-tans✔✔LDLt=tTCt-tHDLt-tTG/5
Whattaretglass,twedgwood,tandtporcelaintmortarstusedtfor?t-tans✔✔Glass-
tusedtfortmixingtliquidst(solutions,tsuspensions)tandtoilytortstainingtcompounds
Wedgwood-tusedtfortgrindingtdrytcrystalstandthardtpowders
Porcelain-tusedttotblendtpowderstandtpulverizetgummytconsistencies
WhattistthetMastertFormulationtRecord?t-
tans✔✔recipetthattprovidestalltingredientstandtinstructionstfortpreparingtatcompoundedtpro
duct.tincludestcompoundtname,tstrength,tdosagetform,talltcalculations,tandteverythingtnee
dedttotmaketthetcompound
Whattistthetcompoundingtlog?t-tans✔✔it'stthetlogtbooktoftalltproductstmadetintthetpharmacy
whattistatQAtplan?t-
tans✔✔qualitytassurancetplantthattoutlinestthetstepstandtactionstthattensuretthetmaintenan
cetoftpropertstandardstfortcompoundingtpreparations.
needsttotbetreviewedtandtupdatedtregularly.
ADRtoftcompoundedtproductstwouldtbetrecordedtwhere?t-
tans✔✔Intthetpharmacy'stcompoundingtrecord
Comminutiont-tans✔✔reductiontoftsolidtparticlesttotsmallertsizetbytcrushingtortgrinding
AKA-triturationtandtlevigation
triturationt-tans✔✔grindingtpowderstintotsmallertparticlestwithtmotortandtpestle
levigationt-tans✔✔triturationtwithtliquidttothelptgrindingtprocess.
givetantexampletoftatlubricanttfortnon-steriletdrytcompoundingt-tans✔✔magnesiumtstearate
Whattistthetpurposetoftatsurfactanttintregardttotdrytcompounding?tGivetantexamplet-
tans✔✔neutralizestatstatictchargetwhichtkeepstthetpowdertfromtfloatingtaway
-sodiumtlaureltsulfate
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