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Exam (elaborations)

NAPLEX- Drug Interactions Questions and answers

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  • NAPLEX
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  • NAPLEX

What are the 3 ways that drugs can be eliminated kidneys (urine) gallbladder (bile) gut (feces) What are the 2 ways that inducers induce CYP enzymes increase the expression of the gene sequence that codes for the enzyme (makes more of the enzyme present) increasing the activity of the e...

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  • September 6, 2024
  • 9
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • NAPLEX
  • NAPLEX
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BRAINBOOSTERS
NAPLEX- Drug Interactions
Questions and answers
What are the 3 ways that drugs can be eliminated - answer kidneys
(urine)
gallbladder (bile)
gut (feces)


What are the 2 ways that inducers induce CYP enzymes - answer
increase the expression of the gene sequence that codes for the
enzyme (makes more of the enzyme present)
increasing the activity of the enzyme (making it work faster)


Enzyme inhibition occurs _____ and typically takes _____ to see effect.
The same is true for its offset. - answer fast; at most a few days


Enzyme induction occurs _____ and typically takes _____ to see effect.
The same is true for its offset. - answer slowly; may take up to 2
weeks; offset can be 2-4 weeks


this is because making more enzymes and killing them off takes a
much longer time


P-gp efflux pump inhibitors - answer itraconazole
ketoconazole
verapamil
ritonorvir
lopinavir/ritonavir
conivaptan

, clarithromycin
erythromycin
amiodarone
quinidine


P-gp efflux pump inducers - answer rifampin
avasimibe
carbamazepine
phenytoin
St Johns wort
tipranavir/ritonavir


Major CYP 3A4 inducers - answer carbamazepine
oxcarbazepine
phenytoin
phenobarbital
primidone
rifabutin
rifampin
rifapentine
smoking
St. Johns wort


Major CYP 2C9 inducers - answer aprepitant
carbamazepine
phenobarbital
phenytoin
primidone

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