CMB2004 Exam Questions With Verified
Answers.
Are B and T lymphocytes part of the adaptive or innate immune response? - answerAdaptive
it is the immune memory evolved over time
What is the clonal selection theory? - answerImmature lymphocytes that could self find are
destroyed
Mature naive ly...
Are B and T lymphocytes part of the adaptive or innate immune response? - answer✔✔Adaptive
it is the immune memory evolved over time
What is the clonal selection theory? - answer✔✔Immature lymphocytes that could self find are
destroyed
Mature naive lymphocytes are mature until they are exposed to antigens
What are the two types of B receptor? - answer✔✔Membrane bound
And released from membrane they are known as antibodies
T cell receptors are only membrane bound and are formed of what heterodimer? -
answer✔✔Alpha and beta chains
Antibodies are formed if a light and heavy chain, what interactions are there between the two? -
answer✔✔Disulphide bridge (Hinge region)
And non covalent interactions
What forms the N terminal region of an antibody? - answer✔✔The antigen binding site of the
light and heavy chain known as the variable region
The C terminal constant region is also known as what? - answer✔✔The FC region (fragment
crystallisable)
The region containing the variable region is called FAB (fragment antigen binding)
Glycosylation of C2 modulates binding of heavy chain
The light chains are either lambda or kappa, what chromosome encodes each? -
answer✔✔Lambda = chromosome 22 - 30 V genes and 7J
Kappa = chromosome 2 - 52 V genes and 5J
There are 5 isotopes of antibody, what are they? - answer✔✔IgM, IgD, IgG, IgE, IgA
How many hyper variable loops are there in total? - answer✔✔6
What are complimentary determing regions? - answer✔✔Sections of the variable region which
bind the antigen
What is an epitope? - answer✔✔the part of an antigen molecule to which an antibody attaches
itself
Can be linear = continuous
Conformational = discontinuous
Multitalented antigen - antigen with more than one epitope
What is MHC called in humans? - answer✔✔Human Leukocyte Antigen (HLA)
Which cells present MHCI?
And MHCII? - answer✔✔I = on all nucleated cells
II = specialised immune cells
Class 1 is formed of heterodimers of alpha and B2 microglobulins what are the three types
encoded by different alpha genes? - answer✔✔HLA-A
HLA-B
HLA-C
Alpha 1 and 2 form beta sheet and the peptide binding cleft
Alpha 3 and beta 2 form ig like domains
CDc8 - stabilisation.
Class 2 is formed if heterodimers of alpha and beta chains with two transmembrane peptides
what are the three tyoes? - answer✔✔HLA-DP
HLA-DQ
HLA-DR
Alpha and beta 1 form the peptide binding cleft
CD4 aid stabilisation
Lymphocyte differentiation involves DNA being broken on purpose and what type of
recombination? - answer✔✔Non homologous end joining
What genes encode the heavy chain (TCRb) variable region ? - answer✔✔V, D and J regions
Light chain (TCRa) = V and J
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