CMB2004 Lecture 4 Exam Questions With Verified Answers
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Course
CMB2004
Institution
CMB2004
CMB2004 Lecture 4 Exam Questions With
Verified Answers
Bone marrow - answerOrigin of haematopoietic stem cells?
Bone Marrow - answerSite of B cell development to the stage of immature B cell?
kappa - answerwhat light chain is expressed first?
negative selection - answerIf BCR expressed by imma...
CMB2004 Lecture 4 Exam Questions With
Verified Answers
Bone marrow - answer✔✔Origin of haematopoietic stem cells?
Bone Marrow - answer✔✔Site of B cell development to the stage of immature B cell?
kappa - answer✔✔what light chain is expressed first?
negative selection - answer✔✔If BCR expressed by immature B cell binds to self cell surface
antigen, the B cell is removed via?
PAX5 - answer✔✔TF that haematopoeitic cells express leading to B cell development
plasma/memory cells - answer✔✔Activated B cells in the periphery can develop into?
Heavy chain - answer✔✔Which Ig chain is re-arranged first
produced by vpreB and gamma 5 to bind to H chain and make sure it works - answer✔✔What is
the surrogate light chain
heavy= V/D/J, Light = V/J = Kappa/Lambda - answer✔✔Which gene segments get re-arranged
in the heavy/light chains?
Activation of B cells to produce plasma cells - answer✔✔Which stage of B cell development
sees the most cell division
Gene recombination, for Heavy/light chain rearrangement - answer✔✔what do the RAG 1 and 2
genes do and when
cell loss (once gamma loci has been tried) - answer✔✔what is the fate of a pre-B cell with non-
productive rearrangements of the light chain genes
clonal deletion/receptor editing - answer✔✔If the BCR expressed on an immune B cell binds
multivalent self antigen, what are the 2 possible outcomes?
thymus - answer✔✔origin of thymocytes?
negative selection based on too high affinity - answer✔✔process of elimination of self-reactive
T cells
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