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MRCP Part 1 - Sexually Transmitted Infections

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  • MRCP Part 1 - Sexually Transmitted Infections

Toxoplasmosis - answer-Raised ICP, headache/vomiting, confusion, seizures, ring enhancing lesions on CTh, reduced vision v low CD4 count 0 - pyrimethamine/sulphadiazine Cryptococcal meningitis - answer-Leptomeningeal enhancement, dilated perivascular spaces, raised ICP, opening opening pressure,...

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  • September 3, 2024
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  • 2024/2025
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  • MRCP Part 1 - Sexually Transmitted Infections
  • MRCP Part 1 - Sexually Transmitted Infections
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MRCP Part 1 - Sexually Transmitted Infections
Toxoplasmosis - answer-Raised ICP, headache/vomiting, confusion, seizures, ring enhancing
lesions on CTh, reduced vision v low CD4 count 0 - pyrimethamine/sulphadiazine

Cryptococcal meningitis - answer-Leptomeningeal enhancement, dilated perivascular spaces,
raised ICP, opening opening pressure, Rx: amphotericin B and flucytosine

Cryptosporidiosis - answer-Self-limiting protozoal, watery diarrhoea, and pain, low grade fevers:
<200 CD4

Pneumocystis jirovecii - answer-Perihilar fluffy opacities (no effusion), dyspnoea, cough, raised
LDH, can cause Ptx, Rx: co-trimox: <200 CD4

CMV encephalitis - answer-Subacute confusion, dementia, CN palsies, CMV retinitis (pizza-pie
fungus v low CD4) - Rx: Ganciclovir

PML - answer-Focal progressive neuropathy, slow onset (weeks-months), JC virus, dementia

Disseminated NTM (nontuberculous mycobacterial) - answer-CD4 <50

Immune reconstituted uveitis - answer-Granulomatous uveitis - when CD4 recovers

High-grade NHL - answer-Pancytopenia, rapidly enlarging lymphadenopathy, significantly
elevated LDH

Kaposi's sarcoma - answer-Single/multiple papular skin lesions, HHV8

Truvada - answer-Emtricitabine/tenofovir = first line PrEP

Tenefovir - answer-Nucleotide reverse transcriptase inhibitors (NtRTI) incl in Truvada: - SE:
kidney disease

Emtricitabine - answer-Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) - incl in
Truvada

Efavirenz - answer-NNRTI (Non-nucleoside reverse transcriptase inhibitor)

Nevirapine - answer-NNRTI (Non-nucleoside reverse transcriptase inhibitor)

Abacavir - answer-Nucleoside analogue

Stavudine - answer-Nucleoside analogue (NRTI) - SE: peripheral neuropathy


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