CFTR (cystic fibrosis transmembrane regulator) gene - ✔✔a gene that codes for a protein involved in
chloride and water transport across membranes. In patients with cystic fibrosis, a mutation in this gene
disrupts chloride and water transport across membranes. The end result is production of thick and
sticky mucus that obstructs the airways in the lungs and the ducts in the pancreas.
nondisjunction - ✔✔Error in meiosis in which homologous chromosomes fail to separate.
lymphocytic leukemia - ✔✔Leukemia characterized by enlargement of lymphoid tissues
and lymphocytic cells in the circulating blood
myelogenous leukemia - ✔✔affects the myeloid cells, which form red blood cells, white blood
cells, and platelets
philadelphia chromosome - ✔✔An abnormal chromosome produced by translocation of parts of the
long arms of chromosomes 9 and 22.
associated with CML
myeloma - ✔✔a type of cancer that occurs in blood-making cells found in the red bone marrow
B cell cancer
, Reed-Sternberg cells - ✔✔cells associated with Hodgkin's lymphoma
Bence Jones proteins - ✔✔Fragments of abnormal immunoglobulins excreted in the urine of
patients with multiple myeloma
FDP (fibrin degradation product) - ✔✔remain in the blood after body dissolves a clot
FSP (fibrin split products) - ✔✔fragments of protein released from a dissolving clot
iron deficiency anemia - ✔✔anemia resulting when there is not enough iron to build hemoglobin
for red blood cells
microcytic hemochromic
pernicious anemia - ✔✔lack of mature erythrocytes caused by inability to absorb vitamin B12 into
the bloodstream
type 1 hypersensitivity - ✔✔IgE mediated
releases a ton of histamine
atopy - ✔✔hypersensitive or allergic state involving an inherited predisposition
autologous - ✔✔graft, donor and recipient are the same
syngeneic - ✔✔grafts from genetically identical individuals
allogeneic - ✔✔grafts, one person donates to another with same HLA
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