Cell Signaling and Cell Junctions in Cancer
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Integrated cell circuit diagrams - ✔✔Interpretation of diagrams representing cell cycle regulation
G1 phase - ✔✔Phase of cell cycle where cell size increases
Rb-E2F interaction - ✔✔Checkpoint at the end of G1 phase in cell cycle
S phase - ✔✔Phase of cell cycle where DNA replication occurs
G2 phase - ✔✔Phase of cell cycle where cell growth and preparation for mitosis occur
M phase - ✔✔Phase of cell cycle where mitosis occurs
Cyclin-CDK interactions - ✔✔Association of cyclin and CDK to regulate cell cycle
Posttranslational modifications - ✔✔Chemical modifications to proteins after translation
MDM2 - ✔✔Protein that regulates p53 in DNA damage response
Flow cytometry - ✔✔Technique to identify cell phenotype and properties
, P53 - ✔✔Protein that regulates cell cycle and DNA repair
Angiogenesis - ✔✔Process of creating new blood vessels
Exchange and diffusion - ✔✔Mechanisms of gas and nutrient exchange in veins, arteries,
and capillaries
Vascular endothelial growth factor - ✔✔Protein involved in angiogenesis and blood vessel formation
Hypoxia-inducible factor 1 (HIF-1) - ✔✔Protein that regulates VEGF release in hypoxic conditions
Tip cells - ✔✔Cells that guide blood vessel formation in angiogenesis
Stalk cells - ✔✔Cells that elongate blood vessel formations in angiogenesis
Pericytes - ✔✔Cells that provide support to newly formed blood vessels
Cytoskeleton - ✔✔Network of filaments that maintain cell shape and enable movement
Microfilaments - ✔✔Smallest cytoskeletal filaments involved in cell movement
Intermediate filaments - ✔✔Cytoskeletal filaments that provide structural support
Microtubules - ✔✔Cytoskeletal filaments involved in cell division and cargo transport
Dynamic instability - ✔✔Fluctuation in length of microtubules
Molecular motors - ✔✔Proteins that utilize the cytoskeleton to move cargo
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