©SOPHIABENNETT@2024-2025 Sunday, August 25, 2024 2:42 PM
Vanderbilt University School of Nursing
VUSN Pharm 2 Final Exam (Week 12)
Practice Questions and Answers
cyclosporine, prednisone, mycophenolate, IgG - Answer✔️✔️-
immunosuppressant prototype drugs
organ transplant introduces foreign tissue to body, immune system
produces IL-2 (type of lymphokine), activation of immune system leads to
destruction and rejection of foreign tissue - Answer✔️✔️-body's response to
organ transplant
IL-2 - Answer✔️✔️-specific lymphokine produced by immune system when
organ transplant occurs
used to suppress immune system, prevent organ/tissue rejection, prevent
tissue destruction, autoimmune diseases - Answer✔️✔️-principals of
immunosuppressant therapy
increased risk for infection and neoplasms - Answer✔️✔️-risks of
immunosuppressant therapy
appropriate, overactive - Answer✔️✔️-immunosuppressants minimize
effects of which immune responses?
benefit of treatment MUST outweigh risks - Answer✔️✔️-important thing to
remember when considering immunosuppressant therapy
calcineurin inhibitor - Answer✔️✔️-cyclosporine class
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, ©SOPHIABENNETT@2024-2025 Sunday, August 25, 2024 2:42 PM
Vanderbilt University School of Nursing
whole organ transplantation (liver, kidney, heart), autoimmune conditions
(rheumatoid arthritis, psoriasis) - Answer✔️✔️-cyclosporine use
inhibits calcineurin (suppresses T-cell proliferation), inhibit production and
release of IL-2 - Answer✔️✔️-cyclosporine ETA
increase levels:
- "azole" antifungals, macrolide antibiotics, Amp-B, grapefruit juice
decrease levels:
- phenytoin, phenobarbital, carbamazepine, rifampin, terbinafine,
trimethoprim/sulfamethoxazole - Answer✔️✔️-cyclosporine interactions
nephrotoxicity (75%), infection (75%), hirsutism, HTN, gingival
hyperplasia, tumor, anemias (s/t suppression of bone marrow) -
Answer✔️✔️-cyclosporine side effects
foods to avoid (don't take w food, decreases absorption), proper med
admin (same time daily), warning s/sx of potential problems - Answer✔️✔️-
cyclosporine client education
assess for allergies and contraindications, assess for baseline organ function
(kidney, liver - LFTs, electrolyte levels), assess for active infection/recent
viral infection, monitor CBC for possible bone marrow suppression (Hct,
Hgb), admin at same time daily as indicated, ensure drug levels are drawn
just prior to admin - Answer✔️✔️-cyclosporine nursing interventions
corticosteroid - Answer✔️✔️-prednisone class
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