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BGM3039 - L22 Exam Questions And Correct Answers
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BGM3039 - L22 Exam QuestionsAnd Correct Answers
what are stem cells - Answer undifferentiated multipotentiated cells which replicate and
differentiate into multiple lineages
what is cell therapy - Answer any therapy where the method of action is driven by
infusing living cells into the human body
what is regenerative medicine and what are some examples - Answer branch of
medicine involved with restoring function
-e.g. engineering cells, tissues and organs
what are some regenerative approaches - Answer -isolate primary cells from
patient/culture
-modify culture with drugs etc.
-tissue engineered
is cell therapy classed as a drug/transplant - Answer HTA and MHRA regulations = drug
what are the sources of cell therapy - Answer autologous
allogenic
xenogenic
what applications do cell therapy cover - Answer -stem cells
-bone marrow
-islets of Langerhans
where are cells infused - Answer -systemic
-target location
what are the 2 mechanisms of action for cell therapy - Answer direct
indirect
what is the direct mechanism of cell therapy - Answer cells engraft, proliferate and
differentiate into tissue for long-term function
what is the indirect mechanism of cell therapy - Answer stimulate repair through
, secreted enzymes e.g. growth factor, cytokines
what does GMP stand for and what is it - Answer good manufacturing practice
-parameter and environment monitoring
-training and procedures
-batch manufacturing records
what are some examples of cell therapy - Answer -bone marrow in immune system
transplant
-CAR-T cells in immunotherapy
-B cell replacement in diabetes
what can haemopoietic stem cell transplants be used as to treat - Answer blood cancer
bone marrow failure
immunodeficiencies
what is an allogenic example of a bone marrow transplant - Answer 1. take stem cells
2. separate, incubate and select
3. decrease volume4. infuse to patient to restore immune system
what does GVHD stand for and what is it also known as - Answer graft vs host disease
-secondary disease
what causes GVHD - Answer incompetent donor cells attacking unrecognised host
tissue Ag
-unwanted side effect of GVL
-most common complication of transplant
what does GVL stand for - Answer graft vs leukaemia
what is the approximate incidence of GVHD - Answer acute 25-50%
chronic 30-70%
what does CAR-T stand for - Answer chimeric antigen receptor T cells
how can CAR-T cells be used as a gene therapy - Answer express CAR protein on T cells
for novel Ag specificity
-target cancer cells
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