al cells,
_____ drugs are used for recruitment and induce non-proliferating clonogenic fraction to enter
into cell cycle - answerCCNS --> Causes increased vulnerability to CCS agents afterwards
since cells are actively dividing.
Adverse effects of CCS drugs - answerThe most rapidly prolifera...
CCS drugs (cell-cycle specific) - answer✔✔Anticancer drugs that are:
--> Phase-specific
--> Higher selective toxicity.
--> More likely to be in-cycle
--> Attack only cells that are actively growing and dividing
CCNS drugs (cell-cycle non-specific) - answer✔✔--> Anticancer drugs that can sterilize tumor
cells regardless of whether they are cycling or resting in G0 Phase
--> Less-selective toxicity and cause damage to healthy cells.
--> More damage to healthy cells
N for non-proliferating, normal cells,
_____ drugs are used for recruitment and induce non-proliferating clonogenic fraction to enter
into cell cycle - answer✔✔CCNS --> Causes increased vulnerability to CCS agents afterwards
since cells are actively dividing.
Adverse effects of CCS drugs - answer✔✔The most rapidly proliferating normal cells are likely
to suffer toxicity along with the tumor cells, but the damage is mostly reversible
--> Bone marrow resumes production
--> Hair regrows,
--> gut and oral mucosa recover.
I <3 rubics cubes - answer✔✔Side effects: Cardiotoxicity
Dexrazoxane: Limits toxicity
Vincristine
Crest = the periphery - answer✔✔Side effects: Peripheral neuropathy
Bleomycin - answer✔✔Pulmonary fibrosis
Surgical debulking - answer✔✔A form of selective toxicity, that allows for large portion of
tumor cells to re-enter cell cycle and proliferate, thus causing death.
Clenogenic fraction (non-growing or non-dividing) are unaffected.
Radiation and cell-cycle non-specific cytotoxic drugs are more broad and cause MORE
COLLATERAL DAMAGE.
Oncolytic viral therapy - answer✔✔One that preferentially infects and kills cancer cells.
Selectively infects lyses only in primary and metastatic cells of that type (eg multiple myeloma)
Multimodal therapy - answer✔✔Chemotherapy, radiation, surgery
CCS are more selectively toxic, but they cannot kill clonogenic fraction cells like CCNS agents.
CCNS agents are used for recruitment (to induce non-proliferating clonogenic fraction to cycle)
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