NR565/ NR 565 Advanced Pharmacology Care of the
Fundamentals midterm exam questions and answers
2024/2025
In patients with infrequent flareups (less than three per year), NSAIDs are the first line
agent for relieving pain - answers Gouty Arthritis Treatment Decision
Prescribe a glucocorticoid (prednisone) or make dietary changes - answers Gouty
Arthritis NSAID Ineffectiveness
Considered for long term treatment if a person has three or more gouty attacks per
year - answers Colchicine Long Term Treatment
Should not be taken with statins or CYP3A4 inhibitors - answers Colchicine
Contraindications
Nausea, vomiting, diarrhea, myelosuppression, myopathy, and rhabdomyolysis -
answers Colchicine Adverse Effects
Can lead to severe cutaneous adverse reaction (SCAR) with symptoms like rash, fever,
eosinophilia, and liver and kidney function issues - answers Allopurinol Long Term
Effect
Should be co-administered with NSAIDs or colchicine - answers Febuxostat Co-
Administration
Erosion and irreversible joint damage, renal damage, and tophi formation - answers
Untreated Gout Complications
Minimize risk of esophagitis by swallowing the pill whole with a full glass of water, then
sitting up for at least 30 min, and taking the med 30 min prior to other intake - answers
Alendronate Patient Education
Interferes with calcium, magnesium, and iron absorption - answers Ibandronate
Dietary Supplement Interference
Alendronate is the first line treatment - answers Osteoporosis 1st Line Treatment
Safe to use in patients with renal dysfunction or who over produce uric acid - answers
Allopurinol Safety in Renal Dysfunction
Includes CBC with WBC differential, s/s of infection, malignancies, pregnancy rule out,
ALT, AST, serum creatinine, comprehensive history and physical exam, and
, assessment of immunocompetence and liver and renal status - answers DMARDs
Baseline Diagnostics
Includes chest x-ray with emphasis on pulmonary and GI status - answers
Methotrexate Baseline Data
Hydroxychloroquine - answers DMARD Requiring Ophthalmologic and Cardiac Exam
Risk for venous thromboembolic events (DVT, PE, stroke) - answers Raloxifene Black
Box Warning
Reinforcing properties of drugs, physical and physiological dependence, social factors,
drug availability, individual vulnerability, impulsivity, low tolerance for frustration, and
specific personality disorders - answers Controlled Substance Addiction Predictors
Adjuvant analgesic for neuropathic pain, effective in diabetic neuropathy, seizures,
central neuropathy, postherpetic neuralgia, and fibromyalgia - answers Pregabalin
Chronic Pain Treatment
Sedation, drowsiness, dizziness, ataxia, blurred vision, and difficulty thinking - answers
Pregabalin Adverse Effects
Linked to COX-2 inhibitors and NSAIDs - answers GI Bleeding Link
Start taking this medicine at the first sign of the attack for best results, stop taking this
medicine as soon as the pain is relieved or at the first sign of nausea, vomiting, stomach
pain, or diarrhea - answers Colchicine Patient Education
Methotrexate, leflunomide, and biologics like anti-TNF agents, rituximab, and abatacept
- answers RA High Risk Drugs in Pregnancy
NSAIDs, corticosteroids, and several DMARDs including sulfasalazine and
hydroxychloroquine - answers RA Safe Drugs in Pregnancy
May increase the risk for myocardial infarction, stroke, and other thromboembolic
events, as well as dangerous gastrointestinal adverse effects such as bleeding,
ulceration, and perforation - answers NSAID Black Box Warning
Interacts with mercaptopurine and azathioprine, warfarin, theophylline, and ampicillin -
answers Allopurinol Drug Interactions
Takes 3 to 6 weeks for symptoms to improve, and 12 weeks or longer for full benefit -
answers Methotrexate Therapeutic Response
Osteonecrosis of the jaw and hip fracture, as well as esophagitis - answers
Bisphosphonates Adverse Effects
