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GMS 6551: Med Pharm Fundamentals Exam | Questions And Answers Latest {} A+ Graded | 100% Verified
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GMS 6551: Med Pharm Fundamentals Exam | Questions And Answers Latest {} A+ Graded | 100% Verified
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GMS 6551: Med Pharm Fundamentals Exam | Questions And Answers Latest {2024- 2025}A+ Graded | 100% Verified
companies - Pharma is made of ---
large - Pharma tends to target diseases that have a --- market
orphan - government incentives tend to target --- diseases
target, receptor, DNA - Drug ---:
the molecule that the drug will interact with:
- enzyme
- ---
- other protein
- ---
- RNA
- Etc.
selectivity, non-human, cancer - ---:
target determines the side effects
-easier to target --- protein
- target mutated --- protein
assay, vitro, vivo, ex - --- development:
- In ---: test tube, cell culture
- In ---: living animals
- --- vivo: tissue
,fast, less, clean, animal - In Vitro:
-advantages:
- ---
- inexpensive
- --- "red tape"
- --- systems
-disadvantages:
- a test tube or cell is not an ---
translate, more, suffering, complex - In Vivo:
- advantage
- results more likely to translate to ---
- disadvantages:
- --- expensive
- may cause --- to animals
- regulations
- --- systems
natural, chemical, rational - Identifying a Lead Compound:
- --- products
- plants, algae, bacteria, and fungi
- --- banks
- thousands or millions
- --- drug design
molecular, crystal, chemical, conformations, cell membrane - Computer Aided Drug Design:
- --- docking: --- structures of many proteins known; program calculates --- attraction
- advantages:
- fast
,- cheap
-disadvantage
- skips a lot of details like --- and the --- ---
lead compound, functionalize, test, compound, new, eliminates, off-target - Structure Activity
Relationships:
- optimize the --- ---
- --- molecule
- test new ---
- choose best ---
- functionalize --- compound
- makes better drug
- --- unneeded functionalization: reduced --- effects
absorption, metabolism, or - Pharmacokinetics:
- ---
- distribution
- ---
- excretion
- in vivo --- in vitro
pharmacology - the study of how chemical substances interact and modulate living systems
pharmacokinetics, pharmacogenetics, toxicology, 20k, 300 - Pharmacology:
- ---
- pharmacodynamics
- ---
- pharmacotherpeutics
- ---
, ~ --- prescription/OTC drugs
~ --- prototypes
drug - any substance that interacts and modulates a living system
agonist - drug that activates biologic response
antagonist - drug that inhibits biologic response
receptors, enzymews - Target of Drug Action:
- primarily --- and ---
propanolol - --- was approved by the FDA as a beta-blocker in 1978
nebivolol - --- was approved by the FDA as a beta-blocker in 2008
dose, circulation, action - Pharmacokinetics:
1) --- of drug
2) drug ---
3) drug/site of ---
pharmacological - the drug/site of action changes the --- effect
pharmacodynamics - --- has a direct effect on the pharmacological effect
mechanism, efficacy - pharmacological effect involves:
1) ---
2) potency
3) ---
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