Routes of Drug Administration Complete Solutions
Why is a drug substance incorporated into various dosage forms for administration by alternative
routes?
To maximize therapeutic response
Dosage forms available for different administration routes
Brainpower
Read More
What are the diffe...
Routes of Drug Administration Complete Solutions
Why is a drug substance incorporated into various dosage forms for administration by alternative
routes?
To maximize therapeutic response
Dosage forms available for different administration routes
Brainpower
Read More
What are the different routes of drug administration?
What are the sublingual and buccal routes of drug administration?
The dosage form is put either under the tongue (sublingual) or in the pouch of the cheek (buccal)
What are the differences between the sublingual and buccal routes of drug administration?
1. Sublingual mucosa is more permeable to buccal one due to higher vascularization and thinner
epithelium - rapid onset of action
2. Sublingual route cannot be used for systemic transmucosal drug administration due to the wash of
the area by saliva, therefore resulting in little time for the drug to be retained at the site of action
What are the general advantages of the sublingual and buccal routes of drug administration?
1. Non-invasive, well-accepted, convenient, accessible
2. The first-pass metabolism by the liver is avoided
3. Drugs can be given to unconscious patients
What are the advantages of the sublingual route of drug administration?
1. Fast onset of drug action due to higher permeability
2. Local action of drugs
What are the advantages of the buccal route of drug administration?
1. Local and systemic effects (oral transmucosal delivery)
2. Suitable for proteins and peptides due to immobile mucosa and extended smooth muscle area
(causes longer retention to the region)
What are the disadvantages of the buccal route of drug administration?
Low drug bioavailability due to low flux of the drug through the buccal mucosa due to low permeability
What are the dosage forms for sublingual and buccal use?
1. Tablets (rapidly disintegrating or bioadhesive)
2. Soft gelatin capsules filled with liquid drug
What is the respiratory route of drug administration?
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