Pharmacology II: IBD and IBS Exam 4
Morrill
Terms in this set (160)
Original
What are the subcategories of IBD
CD
UC
What are the subcategories of IBS
IBS-C
IBS-D
Can affect any part of the GI tract most often it affects the portion of the SI before the large
intestine/colon
Crohns disease
Occurs in the large intestine and the rectum
Ulcerative colitis
Malabsorption tends to occur in what disease
crohns
_______ nutrition should be used when possible; may help facilitate remission induction
Enteral
______ nutrition should be used when bowel rest is indicated
Parenteral
_____ have been studied and thus far have not gained widespread use but further investigations
continue
Probiotics
What probiotics have shown benefit?
Nonpathogenic E. coli, bifidobacteria, lactobacilli, S. thermophilus
How often do you get surgery with IBD
UC: .55-20%
CD:40-55%
Surgery in ___ cases results in high rates of recurrence
CD
When should a pt with IBD get surgery
- if Curative
- fistulas
- uncontrolled with max therapy
- long standing disease
- prophylactic against cancer
, What is the first line medication for mild to severe UC
Mesalamine
Rapidly and completely absorbed in the small intestine but poorly absorbed in the colon --> drug
formulations must be designed to deliver to the affected areas in the GI while preventing premature
absorption
Mesalamine
What are common ADR of mesalamine?
Nausea, vomiting, Headache
Where do sulfasalazine work
colon
Where does rowasa work
rectum- distal colon
Where does canasa work
rectum
wehre does asacol work?
rectum - illeum
where does pentasa work?
rectum - jejunem
Mesalamine enema
rowasa
mesalamine suppository
Canasa
mesalamine coated in a pH resin that dissolves at pH of 6-7 in the distal ileum and colon
Asacol and Apriso
Mesalamine time released microgranules in the SI
Pentasa
Composes of a sulfonamide moiety (sulfapyridine) and
mesalamine (5-ASA) joined by a diazo bond in the same
molecule
Sulfasalazine
First line medication in UC and CD
Sulfasalazine
ADR of sulfasalazine
N/V, Headache, rash, anemia
Severe ADR sulfasalazine
Hepatotoxicity, thrombocytopenia, nephritis
If pregnant and taking sulfasalazine what needs to be added
folate supplement
Used to induce remission in acute moderate to severe UC and CD
Corticosteroids
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