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GMS6504/GMS 6504 University Of Florida -GMS 6504 review exam 2 (P.S. 4-8) Questions With Complete Solutions
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GMS6504/GMS 6504 University Of Florida -GMS 6504 review exam 2 (P.S. 4-8) Questions With Complete Solutions

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  • August 12, 2024
  • 15
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • gms 6504 review exam 2 ps 4 8 questions with c
  • gms6504gms 6504university of florida

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GMS 6504 review exam 2 (P.S. 4-8) Questions With
Complete Solutions


In terms of Lipinski's rules, which of the following functional
groups serves as a hydrogen bond donor?
A. -Cl
B. -NO2
C. =O
D. -SO3
E. -NH2
E. -NH2
Will a hydrophobic molecule have a high or low logP?
A. High
B. Low
A. High
Which is the best explanation as to why CNS drugs tend to have
smaller polar surface areas than drugs that target things outside
of the CNS?

A. The receptors in the CNS tend to be small proteins
B. It helps the drug cross the blood brain barrier
C. Larger drugs will be metabolized faster
D. It will cause them to be sequestered in the brain
E. Absorption is particularly important for CNS drugs

, B. It helps the drug cross the blood brain barrier
Which functional group is most often utilized when making pro-
drugs?

A. Amides
B. Carbonates
C. Ethers
D. Phosphates
E. Esters
E. Esters
Which of the following protein domains would you expect to
find in an “easily druggable” target but NOT in an
“undruggable” target?
A. Extracellular domain
B. Instracellular domain
C. Membrane spanning domain
D. ATP-binding domain
E. Protein binding domain
D. ATP-binding domain
Would using a drug against cells in which it causes synthetic
lethality tend to increase or decrease its therapeutic index?
A. Increase

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