Exam (elaborations)
COAGULATION ASCP EXAM QUESTIONS AND ANSWERS WITH SOLUTIONS 2024
- Course
- Institution
COAGULATION ASCP EXAM QUESTIONS AND ANSWERS WITH SOLUTIONS 2024
[Show more]
Content preview
COAGULATION ASCP EXAMQUESTIONS AND ANSWERS WITH
SOLUTIONS 2024
Platelets are derived from? - ANSWER megakaryocytes
Reference Range for platelets is - ANSWER 150,000-400,000/mm3
Steps in platelet plug formation - ANSWER 1. platelet adhesion
2. platelet release reaction
3. platelet aggregation
Adhesion of Platelet Plug formation includes: - ANSWER Glycoprotein Ib binds to exposed collagen
Requires von Willebrands Factor
Results in release of ADP and other granule components (including Factor V and fibrinogen)
Aggregation of Platelet plug formation - ANSWER Other platelets stimulated by ADP to undergo shape
change exposing the glycoprotein IIb/IIIa complex which binds fibrinogen
Fibrinogen binding links the platelets with weak stimuli, the aggregates can disassociated.
Localization of the platelet plug - ANSWER Secreting platelets release arachidonic acid which converts to
prostaglandin, becomes thromboxane A2 in the platelet.
Arachidonic acid is processed by adjacent endothelial cells to form platelet-inhibiting prostacyclin
Assembly and localization of the fibrin clot. - ANSWER Platelet release fibrinogen, Factor V, and Factpr
VIII
Fibrinogen is bound on the surface at aggregation
Factor VIII is bound to the platelet surface with von Willebrand factors
, Shape change exposes platelet membrane phospholipid
Substrate of Factor I - ANSWER Fibrinogen
Cofactors - accelerate enzymatic reactions are: - ANSWER Factors III (3), V (5) and VIII (8)
Enzymes Serine proteases - ANSWER Cleave peptide bonds (Factors II (2), VII (7), IX (9), X (10), XI (11),
and XII (12))
Contact Proteins are - ANSWER Factors 12, 11, prekallikrein, and HMWK
Participate in initial phase of the intrinsic system
NOT consumed during clotting
NOT vitamin K dependent
Prothrombin Proteins - ANSWER Factors II, VII, IX, X
Vitamin K Dependent
NOT consumed during clotting (Except II)
Present in fresh and stored plasma and serum
Fibrinogen proteins - ANSWER Factors I, V, VIII, XIII
Consumed during clotting
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Performance. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $14.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
77988 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now