MH701 Exam 1:
Neurotransmitters,
AntiDep, Anxiolytics
test(114 questions
fully solved 2024)
What is the most common mistake in a trial
of an antidepressant?
Too low a dosage for too short a time
Before a drug trial can be considered
unsuccessful.....
Raise dosage to maximum recommended
level (if side effects allow it) and maintained
at that level for at least 4-5 (4-8?) weeks.
Sometimes 4-12 weeks required for maximal
improvement. Next option: switch to
different antidepressant within same or
different class.
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What if patient is improving on low dose of
drug?
Keep dose as is (do not raise) unless clinical
improvements stop before maximum benefit
obtained
What if pt is not responding to drug after 2-3
weeks?
Test plasma concentrations, rule out
noncompliance
How long should antidepressant tx be
maintained for first depressive episode? If
had multiple episodes?
, 6 mo (seen 1 year in Stahls')
Might need long-term tx
What would indicate a need for prophylactic
antidepressant treatment?
Episodes that involved SI or impairment of
psychosocial functioning
What is the objective of pharmacologic
treatment for depression?
Remission (NOT just symptom reduction) and
return to baseline function
Define remission
When treatment of depression results in
removal of essentially all symptoms, it is
called remission for the first several months
(e.g., up to 6 months).
Define response
At least a 50% improvement in symptoms
Define recovery
is described as being symptom-free for 6
months or more.
Define relapse
When depression (or other) returns before
there is a full remission of symptoms or
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