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Advanced Pharmacology Exam 1 Questions and Complete Solutions Graded A+
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Advanced Pharmacology Exam 1 Questions and Complete Solutions Graded A+
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Advanced PharmacologyExam 1 Questions and
Complete Solutions
Graded A+
Denning [Date] [Course title]
,Once you graduate from an NP program, in order to prescribe you'll need: - Answer: -Advanced nurse
prescriber license
-DEA #
What is the purpose of a DEA #? - Answer: Needed to prescribed scheduled drugs
Rules for prescribing Schedule II drugs: - Answer: -Written script needed
-1 month supply only
-No refills
What is the PDMP? - Answer: Prescription Drug Monitoring Program
Used to effectively track patient's controlled substance uses across different health facilities (in the same
state)
What are clinical practice guidelines? - Answer: Recommendations that are intended to optimize patient
care that are informed by a systematic review of the evidence and an assessment of the benefits/harms
of alternative care practices
Ex: sepsis, CAP
Common causes of medication errors: - Answer: -Illegible writing
-Drug names that sound alike
-Medications that look alike
-Administering a drug with the wrong route
What is pharmacokinetics? What are its 4 categories? - Answer: What the body does to the drug
1. Absorption
2. Metabolism
,3. Distribution
4. Excretion
Quickest route of absorption? Slowest? - Answer: IV = quickest
IM = slowest
What is the most common way drugs pass through cell membranes? - Answer: Passive diffusion
What characteristics of a drug allow it to pass most quickly through cell membranes (usually through
passive diffusion)? - Answer: Small, uncharged (unionized), lipid soluble--pass through membrane
without any energy
What does it mean when a drug is ionized? - Answer: It means that the drug is stuck in the compartment
it was ionized in and has to be moved to the next compartment (cannot be absorbed into the
bloodstream)
Where do weak acids absorb? - Answer: Stomach
Where do weak bases absorb? - Answer: Small intestine
pH of stomach: - Answer: 2-4
pH of small intestine: - Answer: 6-7
pH of large intestine: - Answer: 6-7
pH of bloodstream: - Answer: 7.35-7.45
pH of bladder: - Answer: 5-8
, pH of breastmilk: - Answer: 7.1
Where will a drug absorb if it is a weak base that ionizes at a pH of 4 and lower? - Answer: In the small
intestine (since the stomach has a pH of 2-4, so the drug will become ionized and move to the small
intestine where it will be able to absorb into the bloodstream)
How can we manipulate the urine pH in cases of overdose? - Answer: Drugs that are weak acids (aspirin)
can be trapped and excreted through the urine.
We raise pH of the urine (with sodium bicarb) to force the drug to ionize and allow it to be excreted, not
reabsorbed through the bloodstream.
What is distribution? - Answer: How a drug will be transported to the tissues it needs to go to in order
for it to exert its effects
Drug factors related to distribution: - Answer: -Lipid solubility
-Molecular size
-Degree of ionization
-Duration of action
-Cellular binding
-Therapeutic effects
-Toxic effects
(lipid soluble, small, and non-ionized drugs will distribute more quickly)
Body factors related to distribution: - Answer: -Vascularity (poor perfusion, disruption of blood flow due
to trauma--difficulty distributing)
-Blood barriers (blood-brain-barrier can be problematic if we need to get drugs to the brain--will need
very high dosing since only a small amount of the drug will get through)
-Transport mechanisms
-Plasma binding proteins
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