pathology for the health professions test 2 Questions And Answers
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Course
Pathology
Institution
Pathology
Explain the pathogenesis of common local symptoms of neoplasia.
~ Local symptoms of neoplasia are often related to compression or
obstruction of normal tissue (e.g.,bronchial obstruction and coughing in a
patient with lung cancer) or are related to erosion and destruction of normal
tissue ...
pathology for the health
professions test 2 Questions
And Answers
what is the main difference between innate and acquired immunity?
✓~ acquired immunity- a pathogen specific and requires previous antigen
exposure and primarily mediated by B AND T lymphocytes
natural immunity-does not require pervious antigen exposure and mediated
primarily by segmented neutrophils
what are the main difference between T AND B lymphocytes and between CD4+
AND CD8+ lymphocytes?
✓~ T lymphocytes undergo selection and maturation in the thymus.
B lymphocytes produce antigen -specific proteins that are secreted into the
blood
cd4- are helper T-lymphoctyes
cd8-are killer t-lymphocytes they kill foreign and virally infected cells
,what are the most important common features and functions of immunoglobulin
?
✓~ IgG-efficient at activating complement and targeting pathogens for
phagocytosis
IgM-Provide 1st line of defense against bacterial polysaccharides
IgA- found in saliva tears and bodily secretions
IgD- cell membrane associated and serves a receptor for early B-cell activation
IgE- antibodies are bound to the surface of mast cells, providing an antigen-
specific receptor for mast cell activation and degranulation
what is the role of the major histocompatibility complex and cytokines in the
response to foreign antigens?
✓~ MHC-a gene cluster that encodes cell-surface glycoproteins
cytokines-regulate the activity of other effector cells through complex
paracrine signaling mechanisms
what is the mechanism of type 1 hypersensitivity?
, ✓~ reflects mast cell degranulation with the release of histamine and
other vasoactive mediation of acute inflammation
what does type 1 hypersensitivity requires?
✓~ pervious exposure to a pathogen, which results in the generation of
IgE antibody
what are the two basic mechanisms of type 2 hypersensitivity?
✓~ 1- complement-mediated tissue hemolysis and or damage
2-antibody dependent cellular cytotoxicity(ADCC)
Which diseases are caused by type 2 hypersensitivity reaction?
✓~ -graves disease
-myasthenia gravis
-goodpasture syndrome
Which diseases are caused by type 3 hypersensitivity reaction?
✓~ -systemic lupus erythematosus
-polyarteritis nodosas
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