, Mechanism of action: Typical/Traditional/conventional antipsychotics - CORRECT ANSWER Block
dopamine receptors (D2), consistent with dopamine hypothesis
Dopamine hypothesis - CORRECT ANSWER Positive sx caused by excessive dopamine in brain or
excessive sensitivity of dopamine receptors in affected ppl
Support for dopamine hypothesis - CORRECT ANSWER -Overdose on amphetamines causes
hallucinations that mimic positive schizophrenia sx similar to acute phase
-Low doses of amphetamines tend to exacerbate sx for people with schizophrenia
Three classes of side effects for typical antipsychotics - CORRECT ANSWER -Anticholinergic effects
-Appear early, with tolerance developing within weeks or months
Extrapyramidal effects - CORRECT ANSWER Side Effects of Traditional Antipsychotics
-Problems related to movement, since we are targeting dopamine in the caudate nucleus
-Parkinsonism
-Akathisia (nasty restlessness)
-Acute dystonia (muscle spasms in face, mouth, neck)
-Tardive Dyskinesia
Tardive Dyskinesia - CORRECT ANSWER -Occurs late and more often in women and older patients
-Involves involuntary movements of the lips and tongue (lip-smacking)
-Similar to Huntington's Disease
-More common in women, older patients
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