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NR 507 MIDTERM STUDY GUIDE
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NR 507 MIDTERM STUDY GUIDE
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NR 507 MIDTERM STUDY GUIDEHypersensitivity: Type 1 - answer- -Mediated IgE
-inflammation due to mast cell degranultion
-anaphylactic, asthma, hay fever
treatment: epinephrine
Hypersensitivity: Type 2 - answer- -Cytotoxic reaction: tissue specific
-binds to the antigen ON THE CELL SURFACE
-macrophages are primary effectors cells involved
cause tissue damage or alter function
Hypersensitivity 2 - answer- -Graves Disease (hyperthyroidism) -alters function not
destroy
-blood transfusions reaction- transfused erythrocytes are destroyed by agglutination or
lysis
-drug allergies
-hemolytic anemia
Hypersensitivity: type 3 - answer- -Not organ specific
-antibody binds to soluble antigen OUTSIDE THE CELL SURFACE that was released
into the blood or bodily fluids, and the complex is then deposited in the tissues
___ measures the average size of RBCs - answer- MCV
Anemia occur by... - answer- -impaired RBC production
-excessive blood loss
- increased RBC production
microlytic anemia is characterized by hyper chromic RBS: - answer- Hereditary
spherocytosis
Anemia - answer- -"without blood"
4.7-6.1mcl - answer- Normal for men RBC
4.5-5.2mcL - answer- Normal for women RBC
13.5-17.5 - answer- Normal hemoglobin for men
12.0-15.5 g/dL - answer- Normal hemoglobin for women
RBC - answer- The number of erythrocytes in 1 cubic mm of whole blood
Hemoglobin (Hgb) - answer- The oxygen-carrying pigment of red cells
, Hematocrit (Hct) - answer- The volume of cells as a % of total volume of cells and
plasma in whole blood
42-45% - answer- Normal for HCT for men
37-48% - answer- Normal HCT for women
Mean Cell Volume (MCV) - answer- Measures the average size of the RBC
80-100 fL - answer- Normal MCV
RDW (red cell distribution width) - answer- Estimate of the uniformity of individual cell
size
11.5- 14.5% - answer- Normal RDW
Microcytic (MVC <80fL) - answer- Iron deficiency
Microcytic (MVC <80fL) less than - answer- Sideroblastic
Microcytic (MVC <80fL) - answer- Thalassemia
Microcytic (MVC <80fL) - answer- Anemia of chronic disease
Normocytic (MVC 80-99) - answer- Anemia of inflammation and chronic disease
Normocytic (MVC 80-99) - answer- Hereditary spherocytosis
Normocytic (MVC 80-99) - answer- G6PD deficiency
Normocytic (MVC 80-99) - answer- Paroxysmal nocturnal hemglobinuria
Macrocytic (MVC >100) greater than - answer- B12 deficiency (pernicious anemia)
Macrocytic (MVC >100) greater than - answer- Folate deficiency
Hypochromic anemia -(MCHC) less than normal hemoglobin - answer- RBCs pale in
color
Normochromic anemia -(MCHC) normal hemoglobin - answer- Neither pale or dark
Hyperchromic anemia - (MCHC) more than normal hemoglobin - answer- Dark rue or
red
Manifestations of anemia - answer- fatigue, pallor, weakness, dyspnea, dizziness,
tachycardia
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