This visual illustration displays the Usage of Triglycerides (fats and lipids) within the human body, step by step. It includes all reactants, products, enzymes, factors, and organs/systems involved.
Mobilization of Triglycerides
lipolysis : breakdown of fats/lipids/triglycerides
* occurs in
fasting state *
Adipocyte
=
·
onis
O
,
3
CGI disassociates
is
perilipin-normally alpha cells in
pancreas release glucagon when
when perilipin
phosphorylated
cAMP
adenyly/ D
whenThes hormonbintproteinpedrecepti converts ATP to cAMp
cyclase AC
effector enzyme adenyly/ . . .
MGL
mono-glyceride
lipase
pineph (20 ) %
lycerol is soluble
calcohol
groups) so
J
it can enter blood
2, 3 .
PKA phosphorylates perilipin ,
which causes unassisted
-
C61 to dissociate from perilipin.
1
4
. 261 binds to and activates Adipose
Triglyceride Lipase (ATGL)
(TAG)
. ATGL
5 cuts an ester bond on the triglyceride ↑
to release I free fatty acid (FFA) ↑
and activates
phosphorylates
↓
6 .
PKA then ↑
which
Hormone-Sensitive Lipase (HSL) ↑
6
,
diacylglycerol (DAG
↑
From here , albumin can
o
releases 1 FFA from ↑
& ↑
FFAs to
↑
transport
repeats with Mono-Glyceride V
&
- to be
. The same
7
3rd FFA
& other tissues
ATP
which
cuts oxidized to make
Lipase (MGL)
M
the
C
-
Stream
,
and glycerol from monoacyl glycerol (MAG) - -
-
end product : 3 FFAs + 1 glycerol
ATGL-TAG-FFAI
HSL-DAG-FFAZ
MGL- MAG-FFA2 +
glycerol
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