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N450 - Drug Overdose_ Poisoning (1).

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N450 - Drug Overdose_ Poisoning (1).

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  • July 25, 2024
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  • 2023/2024
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N450 - Drug Overdose/ Poisoning
sx - anorexia, nausea, and malaise - ANS-acetaminophen - phase 1

up to 24 hours post-ingestion

sx - increase AST/ ALT with prolongation of PT - ANS-acetaminophen - phase 2

24-48 hours post-ingestion

sx - peak hepatotoxicity, coagulopathies, and jaundice - ANS-acetaminophen - phase 3

72-96 hours post-ingestion

acetylcysteine - ANS-acetaminophen antidote

sx - CNS/ respiratory depression, constricted pupils, hypotension, hypothermia, and
hyporeflexia - ANS-opioid overdose

narcan - ANS-opioid antidote

sx - delirium, dry/ flushed skin, dilated pupils, increased temperature, decrease bowel sounds,
urinary retention, tachycardia - ANS-anticholinergics overdose

physostigmine (with fluids) - ANS-anticholinergics antidote

sx - increase salivation/ lacrimination/ urinary output, diarrhea, emesis, diaphoresis,
bradycardia, fasciculation's, CNS depression, and constricted pupils - ANS-cholinergic overdose

atropine, 2 pAM, and diazepam - ANS-cholinergic antidote/ treatment

sx - agitation, arrhythmia, angina, tachycardia, HTN, hyperthermia, seizures, sweating,
metabolicc acidosis - ANS-sympathomimetic overdose

agents - cocaine, ADHD medications, or amphetamines - ANS-sympathomimetic agents

benzodiazepines and labetolol - ANS-sympathomimetic antidote/ treatment

sx - hypotension, hypothermia, normal to low pulse, low respires, drowsiness, slurred speech,
ataxia, and lethargy to coma - ANS-sedative/ hypnotics overdose

flunazeil - ANS-for benzodiazepines overdoses

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