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2023/2024 NURS 5334Pharm StudyGuide Quiz 1Latest UpdateBest ExamSolution Graded A+
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2023/2024 NURS 5334Pharm StudyGuide Quiz 1Latest UpdateBest ExamSolution Graded A+
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12/4/23, i4:44 iPM 2i2023 -2024 iNURS i5334 iPharm iStudy iGuide iQuiz i1iLatest iUpdate iBest iE… about:blank 1/83 2023/2024 NURS i5334 Pharm iStudy iGuide iQuiz i1 iL
atest iUpdate iB
est iExam iSolu
tion iGraded iA
+ 12/4/23, i4:44 iPM 2i2023 -2024 iNURS i5334 iPharm iStudy iGuide iQuiz i1iLatest iUpdate iBest iE… about:blank 2/83 NURS i5334 iPHARM MODULE i1 • What iare ithe iBON irules iand iregulations ifor iprescriptive iauthority ifor it
heiadvance ipractice inurse? • Texas iisivery irestricted • Describe ithe ipharmacokinetic iprocesses iofiabsorption, idistribution, im
etabolism iand ielimination iand ihow idifferences iinithese iareas iaffect idru
giaction. • Absorption • Drug’s imovement ifrom ithe isite iofiadministration iinto ithe ib
lood. • Distribution • Drug’s imovement ifrom ithe iblood iinto ithe iinterstitial ispace io
fitissues iand ifrom ithere iinto icells. • Metabolism • Biotransformation iisithe ienzymatically imediated ialteration iofid
rug istructure. • Elimination • Combination iofimetabolism iand iexcretion • Discuss ithe iimpact iofifood ionidrug iabsorption, idrug imetabolism iand ionid
rug itoxicity iand iaction—asiwell iasithe itiming iofidrug iadministration. LIFESPAN • Hepatic imetabolism iand iGFR iincrease iduring ipregnancy, idosages iofis
ome idrugs imay ineed itoibeiincreased. • Rate iofialbumin itoiwater idecreases • Third itrimester: iRenal iblood iflow iisidoubled iand irenal ie
xcretion iisiaccelerated i(drugs iexcreted irapidly) • Tone iand imobility iofibowel idecrease • Prolongation iofidrug ieffects iTotal i(½ilife iincreases) Understand istages iofidevelopment iinipregnancy 12/4/23, i4:44 iPM 2i2023 -2024 iNURS i5334 iPharm iStudy iGuide iQuiz i1iLatest iUpdate iBest iE… about:blank 3/83 • Conception: ithrough iweek i2 • Embryonic iperiod: iweek i3-week i8 a) Gross imalformations ican ibeiproduced ibyiteratogens • Fetal iperiod: iweek i9-delivery • Understand ipregnancy ilabeling • 3icategories inow a)iPregnancy, ilactation, imale i&ifemale ireproductive ipotential • How idoiyou idecrease irisk iinithe iinfant iduring ibreastfeeding? • Take imeds iimmediately iafter ibreastfeeding, iavoid idrugs ithat ih
ave ilong ihalf-
lives, ichoose idrugs ithat itend itoibeiexcluded ifrom imilk, iavoid id
rugs ithat iare iknown itoibeihazardous. • How idoipediatric ipatients idiffer iinitheir iresponse itoimedications? • Absorption a) Oral? • Neonates: idrug iremain iinithe istomach ilonger iwhic
hiincreases ithe ilevels, ilow iacidity ican iaffect ithe iab
sorption iofiacid ilabile idrugs b) Parenteral? • Reponses iare islow iand ierratic. • Infancy: iabsorption iisimore irapid ithan iinineonates i
&iadults • Best iavoided iiniinfants c) Transdermal? • Greater iskin ipermeability iwhich iincreases itopi
calidrug iabsorption iand iincreases ithe irisk iforito
xicity • Distribution a) Protein ibinding 12/4/23, i4:44 iPM 2i2023 -2024 iNURS i5334 iPharm iStudy iGuide iQuiz i1iLatest iUpdate iBest iE… about:blank 4/83 1. Neonates: iless iprotein -binding—
increased iavailability iofihighly iprotein ibound idrug
sisuch iasiphenytoin, idiazepam, iand iphenobarbital. i
Reduced idosages ineeded iinithese ihighly ibound idrug
s. b) Blood iBrain iBarrier 1. Not ifully ideveloped iatibirth, idrugs ihave ieasy ia
ccess itoithe iCNS, idoses ishould ibeireduced. • Metabolism a) Hepatic ifunction? 1. Liver ihasn’t ireached ifull imaturation —
sensitive itoidrugs ieliminated ibyithe iCYP450. iLive
r’siability itoimetabolize idrugs iincreases iabout ione i
month iafter ibirth. b) Tihalf ilife 1. Decreased ibyiasimuch iasi48-72ihours • Excretion a) Renal? 1. GFR iisisignificantly ireduced iatibirth, idrugs ielimina
ted ibyithe ikidneys imust ibeigiven iiniaireduced idosag
eiand ilonger idosing iintervals. • What ieducation ineeds itoibeigiven itoiparents? • What itoidoiifichild ispits iout imedication iorithrows iitiup • Effective ieducation: idosage isize iand itiming, iroute, itechnique io
fiadministration, iduration iofitreatment, ihow itoistore ithe idrug, in
ature iand itime icourse iofithe idesired iresponse, inature iand itime ic
ourse iofiadverse ireactions. • Compare iand icontrast ipharmacokinetics iand ipharmacodyna
mics iofispecial ipopulations —pediatrics, iolder
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