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COMSAE Drugs – Complete Study Guide
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COMSAE Drugs – Complete Study Guide
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COMSAE Drugs – Complete Study GuideWarfarin- Mechanism Correct Ans - Interferes w/ vitamin K dependent clotting factors (II, VII, IX, X, C, S)
Warfarin- Pathway, effect on PT/INR Correct Ans - Extrinsic factor, increased PT
Warfarin- Clinical Use Correct Ans - Chronic anticoagulation
Warfarin- Pregnancy Correct Ans - CI in pregnant women--crosses placenta
Warfarin- AE Correct Ans - Bleeding, tissue necrosis
Digoxin- MOA Correct Ans - Direct inhibition of Na/K ATPase --> indirect
inhibition of Na/Ca exchange
Increased Calcium concentration --> positive ionotropy.
Stimulates vagus nerve --> decrease HR
Digoxin- Clinical use Correct Ans - Heart failure (increase contractility)
atrial fibrillation (decrease conduction at AV node and depression of SA node)
Digoxin- AE Correct Ans - Hyperkalemia, blurry yellow vision, arrhythmias, AV block
Digoxin Toxicity- Treatment Correct Ans - Slowly normalize K+, cardiac pacer, anti-digoxin Fab fragments, Mg+
Beta Blockers- Mechanism Correct Ans - Decrease SA and AV nodal activity by decreasing cAMP/Ca2+
Decrease slope of phase 4
Beta Blockers- Use Correct Ans - SVT, ventricular rate control for a-fib and a-flutter
Beta Blockers- AE Correct Ans - Exacerbation of COPD/asthma
CV effects: bradycardia, AV block, HF
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