NR 293 QUESTIONS AND ANSWERS LATEST UPDATE
Pharmaceutics
The dosage form the determines the rate of drug dissolution
Pharmacodynamics
therapeutic effects /the way the drugs act on the body
"what the drug does to the body"
Pharmacokinetics
what the body does to the drugs
ADME
ADME
abso...
Pharmaceutics
The dosage form the determines the rate of drug dissolution
Pharmacodynamics
therapeutic effects /the way the drugs act on the body
"what the drug does to the body"
Pharmacokinetics
what the body does to the drugs
ADME
ADME
absorption
distribution
metabolism
Excretion
Absorption
being absorbed by the tissue; relates to route of medication
fastest to slowest route of medication by mouth
sublingual
liquid suspension
capsule
tablet
enteric coated tablet
extended release tablet
bio-availability
amount of drug that actually reaches circulation
paternal drugs have....
, 100% initial bio-availability because they bypass the liver
first pass effect
initial liver metabolism
Oral drugs
are metabolized in the liver prior to the blood stream and will NOT have the same bio-
availability as IV drugs
drugs NOT affected by first pass effect
IV, sublingiual, transdermal path, suppository(parenteral)
durgs affected by first pass effect
Elixir, tablets, capsules (enternal)
Half/Life
the time it takes for 1/2 the drug to be eliminated in the body
Distribution
how drugs become available to action site
Distribution sites
plasma, interstitual fluid, intracellular fluid, transcellular fluid
Fast distribution
Heart and Liver
Slow Distribution
Muscle, Fat, Skin
Protein binding
many drug bind to protein in the blood, if a person has a lower albumin level, free drugs
will circulate causing toxicity of the drug,
Normal albumin level prescribed more then one medication=
decrease in dose to avoid drug toxicity
low albumin level =
fewer protein binding site which can lead to toxicity
commonly used protein bound drugs
furosemide
aspirin
Ibuprofen
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