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Test Bank For Pharmacology for Nurses A Pathophysiological Approach, 6th Edition by Michael P. Adams; Norman Holland, All Chapters 1 - 50, Verified Newest Version$14.99
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Test Bank For Pharmacology for Nurses A Pathophysiological Approach, 6th Edition by Michael P. Adams; Norman Holland, All Chapters 1 - 50, Verified Newest Version
Test Bank For Pharmacology for Nurses A Pathophysiological Approach, 6th Edition by Michael P. Adams; Norman Holland, All Chapters 1 - 50, Verified Newest Version
GEN ERAL PHARMACOL OGY 1. All of the following are general mechanisms of drug permeation Except (a) Aqueous diffusion (b) Aqueous hydrolysis (c) Lipid diffusion (d) Pinocytosis or endocytosis (e) Special carrier transport 2. If the plasma concentration of a drug declines with “first -order kinetics”, this means that (a) There is only one metabolic path for drug disposition (b) The half -life is the same regardless of the plasma concentration (c) The drug is largely metabolized in the liver after oral administration and has low bioavailability elimination (d) The rate of climination is proportionate to the rate of administration at all times (e) The drug is not distributed outside the vascular system 3. Regarding termination of drug action (a) Drug must be exerted from the body to terminate their action (b) Metabolism of drugs always increases their water solubility (c) Metabolism of drugs always abolishes their pharmacologic activity (d) Hepatic metabolism and renal excretion are the two most important mechanisms involved (e) Distribution of a drug out of the bloodstream terminates the drug’s effect 4. Distribution of drugs to specific tissues (a) Is independent of blood flow to the organ (b) Is independent of the solubility of the drug in that tissue (c) Depends on the unbound drug concentration gradient between blood and tissue (d) Is increased for drugs that are strongly bound to plasma proteins (e) Has no effect on the half-life of the drug 5. A physical process by which a weak acid becomes less water -soluble and more lipid-soluble at low pH is (a) Distribution (b) Elimination (c) First-pass effect (d) Permeation (e) Protonation 6. Dose -response curves are used for drug evaluation in the animal laboratory and in the clinic, Quantal dose -response curves are often (a) Used for determining the therapeutic index of a drug (b) Used for determining the maximal efficacy of a drug (c) Invalid in the presence of inhibitors of the drug being studied (d) Obtained from the study of intact subject but not from isolated tissue preparations MCQs IN PHARMACOLOGY 2 (e) Used to determine the statistical variation (standard deviation) of the maximal response to the drug. 7. The following are excreted faster in basic urine (a) Weak acids (b) Strong acids (c) Weak Bases (d) None of the above 8. Which of the following statements about spare receptors is most correct ? (a) Spare receptors, in the absence of drug, are sequestered in the cytoplasm (b) Spare receptors will be detected if the intracellular effect of drug-receptor interaction lasts longer than the drug-receptor interaction itself (c) Spare receptors influence the maximal efficacy of the drug -receptor system (d) Spare receptors activate the effector machinery of the cell without the need for a drug (e) Spare receptors may be detected by the finding that the EC50 is greater than the Kd for the agonist 9. Which of the following terms best describes an antagonist that interacts directly with the agonist and not at all or only incidentally, with the receptor ? (a) Pharmacological antagonist (b) Partial agonist (c) Physiological antagonist (d) Chemical antagonist (e) Noncompetitive antagonist 10. Which of the following terms best describes a drug that blocks the action of epinephrine at its receptors by occupying those receptors without activating them ? (a) Pharmacological antagonist (b) Partial agonist (c) Physiological antagonist (d) Chemical antagonist (e) Noncompetitive antagonist 11. Which of the following provides information about the variation in sensitivity of the drug within the population studied ? (a) Maximal efficacy (b) Therapeutic index (c) Drug potency (d) Grade dose-response curve (e) Quantal dose-response curve 12. Which of the following most accurately describes the transmembrane signaling process involved in steroid hormone action ? (a) Action on a membrane spanning tyrosine kinase (b) Activation of a G protein which activates or inhibits adenyl cyclase (c) Diffusion into the cytoplasm and binding to an intracellular receptor (d) Diffusion of “STAT” molecules across the membrane (e) Opening of transmembrane ion channels 13. Which of the following is a phase II drug- metabolizing reaction ? (a) Acetylation (b) Deamination (c) Hydrolysis (d) Oxidation (e) Reduction 14. Which of the following drugs may inhibit the hepatic microsomal P450 responsible for warfarin metabolism (a) Cimetidine (b) Ethanol (c) Phenobarbital (d) Procainamide (e) Rifampin 15. With regard to clinical trials of new drugs, which of the following is most correct ? (a) Phase I involves the study of a small number of normal volunteers by highly trained clinical pharmacologists (b) Phase II involves the use of the new drug in a large number of patients (100 -5000) who have the disease to be treated (c) Phase III involves the determination of the drug’s therapeutic index by the cautious induction of toxicity (d) Chemical antagonist (e) Phase II requires the use of a positive control (a known effective drug) and a placebo 16. Animal testing of potential new therapeutic agents GENERAL PHARMACOLOGY 3 (a) Extends over a time period of at least 3 years in order to discover late toxicities (b) Requires the use of at least two primate species, eg. Monkey and baboon (c) Requires the submission of histopathologic slides and specimens to the FDA for government evaluation (d) Has good predictability for drug allergy -type reactions (e) May be abbreviated in the case of some very toxic agents used in cancer 17. The “dominant lethal” test involves the treatment of a male adult animal with a chemical before mating; the pregnant female is later examined for fetal death and abnormalities. The dominant lethal test therefore is a test of (a) Teratogenicity (b) Mutagenicity (c) Carcinogenicity (d) All of the above (e) None of the above 18. The Ames test is a method for detecting (a) Carcinogenesis in rodents (b) Carcinogenesis in primates (c) Teratogenesis in any mammalian species (d) Teratogenesis in primates (e) Mutagenesis in bacteria 19. “Nicotinic” sites include all of the following except (a) Bronchial smooth muscle (b) Adrenal medullary cells (c) Parasympathetic ganglia (d) Skeletal muscle (e) Sympathetic ganglia 20. A good example of chemical antagonism (a) Heparin & Protamine (b) Protamine & Zinc (c) Heparin & Prothrombin (d) All the above 21. Which of the following agents is a pro- drug that is much less toxic in mammals than in insects ? (a) Acetylcholine (b) Bethanechol (c) Physostigmine (d) Pilocarpine (e) Neostigmine 22. Phenylephrine causes (a) Constriction of vessels in the nasal mucosa (b) Increased gastric secretion and motility (c) Increased skin temperature (d) Miosis (e) All of the above 23. Pretreatment with propranolol will block which one of the following ? (a) Methacholine -induced tachycardia (b) Nicotine -induced hypertension (c) Norepinephrine -induced bradycardia (d) Phenylephrine -induced mydriasis 24. Most drug receptors are (a) Small molecules with a molecular weight between 100 and 1000 (b) Lipids arranged in a bilayer configuration (c) Proteins located on cell membranes or in the cytosol (d) DNA molecules (e) RNA molecules 25. With regard to distribution of a drug from the blood into tissues (a) Blood flow to the tissue is an important determinant (b) Solubility of the drug in the tissue is an important determinant (c) Concentration of the drug in the blood is an important determinant (d) Size (volume) of the tissue is an important determinant (e) All of the above are important determinants 26. The pH value is calculated mathematically as the (a) Log of the hydroxyl ion (OH–) concentration (b) Negative log of the OH– concentration (c) Log of the hydrogen ion (H+) concentration (d) Negative log of the H+ concentration (e) Ratio of H+/OH– concentration 27. Which property is classified as colligative? (a) Solubility of a solute (b) Osmotic pressure MCQs IN PHARMACOLOGY 4 (c) Hydrogen ion (H+) concentration (d) Dissociation of a solute (e) Miscibility of the liquids 28. The colligative properties of a solution are related to the (a) pH of the solution (b) Number of ions in the solution (c) Total number of solute particles in the solution (d) Number of unionized molecules in the solution (e) pKa of the solution 29. The pH of a buffer system can be calculated with the (a) Noyes – Whitney equation (b) Henderson – Hasselbalch equation (c) Michaelis – Menten equation (d) Yong equation (e) Stokes equation 30. Which mechanism is most often responsible for chemical degradation? (a) Racemization (b) Photolysis (c) Hydrolysis (d) Decarboxylation (e) Oxidation 31. Which equation is used to predict the stability of a drug product at room temperature from experiments at accelerated temperature? (a) The stokes equation (b) The Yong equation (c) The Arrhenius equation (d) The Michaelis – Menten equation (e) The Hixson – Crowell equation 32. Based on the relation between the degree of ionization and the solubility of a weak acid, the drug aspirin (pKa 3.49) will be most soluble at (a) pH 1.0 (b) pH 2.0 (c) pH 3.0 (d) pH 4.0 (e) pH 6.0 33. The particle size of the dispersed solid in a suspension is usually greater than (a) 0.5 m (b) 0.4 m (c) 0.3 m (d) 0.2 m (e) 0.1 m 34. In the extemporaneous preparation of a suspension, levigation is used to (a) Reduce the zeta potential (b) Avoid bacterial growth (c) Reduce particle size (d) Enhance viscosity (e) Reduce viscosity 35. Active transport differs from facilitated transport in following ways, except (a) Carrier is involved (b) It is against concentration gradient (c) Energy is required (d) All of the above 36. Vanishing cream is an ointment that may be classified as (a) A water –soluble base (b) An oleaginous base (c) An absorption base (d) An emulsion base (e) An oleic base 37. Rectal suppositories intended for adult use usually weigh approximately (a) 1g (b) 2g (c) 3g (d) 4g (e) 5g 38. In the fusion method of making cocoa butter suppositories,which substance is most likely to be used to lubricate the mold? (a) Mineral oil (b) Propylene glycol (c) Cetyl alcohol (d) Stearic acid (e) Magnesium silicate 39. A very fine powdered chemical is defined as one that (a) Completely passes through a # 80 sieve (b) Completely passes through a # 120 sieve (c) Completely passes through a # 20 sieve (d) Passes through a # 60 sieve and not more than 40% through a # 100 sieve (e) Passes through a # 40 sieve and not more than 60% through a # 60 sieve
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