NR565- Advance Pharmacology
· Amlodipine
Common dose
Directions for use
Indication - correct answer-Essential HTN & Angina
5-10mg/daily
· Colchicine
Common dose
Directions for use
Indication - correct answer-Gout attack
start tx at the first sign of attack, and stop use is side effects occur
0.6-1.2mg q12-daily as recommended
· Hydrocodone/Acetaminophen (Lortab)
Common dose
Directions for use
Indication - correct answer-Pain
5mg/325mg- 1-2 tabs q4-6h
7.5mg/325mg- 1tab q4-6h
10mg/325mg- 1tab q4-6h
· Lisinopril
Common dose
Directions for use
Indication - correct answer-HTN- 10-40 mg once/d
HF- 20-40 mg once/day
Acute MI- 10 mg once/day for at least 6 weeks
Atherosclerotic Cardiovascular Disease (ASCVD) Risk Score
o What is it?
o When is it used? - correct answer-ASCVD risk assessment is directed at determining the
patient's absolute risk of developing the clinical coronary disease over the next 10 years.
Defines high risk as 7.5% or greater. A calculation of your 10-year risk of having a
cardiovascular problem, such as a heart attack or stroke.
In children, screening should be done between ages 9 and 11 and then again at ages 19 and
21. For adults every 5 years after the age of 20. Some people are at greater risk like those
with diabetes and a risk score greater than 7.5% and should be screened more often
Be familiar with pharmacokinetic and pharmacodynamic changes of older adults and how
that would translate to baseline information needed to prescribe. - correct answer-increase
glomerular filtration rate leads to increase drug excretion
increase hepatic metabolism
decrease tone and motility of bowel
, increase drug absorption
Beer's Criteria- What is it and Why is it important - correct answer-Recommendations of
medications inappropriate for elderly (65 and older)
Prevents adverse drug reactions
Behaviors that predict controlled substance addiction - correct answer-chronic pain
family history
other substance abuse
prescribed for long-term use
Best approach or drug to use for HTN during pregnancy or someone wishing to become
pregnant - correct answer-labetalol
methyldopa
nifedipine
Beta-blockers
o Their use with nitroglycerin and tachycardia
o Know examples
o Risk of stopping them abruptly
o What happens when given to someone with asthma? - correct answer--Beta Blockers
suppress nitroglycerin-induced tachycardia.
They do so by preventing sympathetic activation of beta-1 adrenergic receptors in the heart.
-End in -olol
-Stopping abruptly can increase the incidence and intensity of anginal attacks and may even
precipitate MI
-May cause bronchospasms
Black Box Warnings
o What are they?
o Why are they issued? - correct answer-Is the strongest safety warning a drug can carry
and still remain on the market. Usually presented on the label with a heavy black border.
Issued by the FDA due to having serious or life-threatening risks
Buprenorphine and Naloxone
o Benefit of using this combination - correct answer-Naloxone is added to buprenorphine to
decrease the likelihood of diversion and misuse of the combination drug product
CDC Guiding principles for prescribing opioids - correct answer-Opioids are not first-line
therapy
Establish goals for pain and function
Discuss risks and benefits
Use immediate-release opioids when starting
Use the lowest effective dose
Prescribe short durations for acute pain
Evaluate benefits and harms frequently
Use strategies to migrate risk
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