DIC: Collaborative Management - ANS-Treat the underlying cause
Prevent/manage septic shock - IV fluid boluses for low BP
Support organ function
Early detection of bleeding
Bleeding precautions
Blood products
Packed RBCs
FFP (Fresh Frozen Plasma)
Platelets
Plasma volume expanders
, Disseminated Intravascular Coagulation (DIC) - ANS-Not a disease!!
Serious bleeding and thrombotic disorder
Results from abnormally initiated and accelerated clotting
Decreases in clotting factors and platelets ensue
May lead to uncontrollable hemorrhage
Abnormal response of the clotting cascade stimulated by a disease process or disorder
A systemic activation of the coagulation system simultaneously leads to thrombus
formation and exhaustion of platelets and coagulation factors (results in hemorrhage).
Life threatening - mortality is > 80%
HL & NHL: Assessment - ANS-Enlarged but painless lymph nodes
Usually in neck with HL
Fever*
Weight loss
Fatigue
Infections
Diagnosis
CBC
Lymph node biopsy
Bone marrow aspiration
PET scan CT scan
Hodgkin's Lymphoma - ANS-Most treatable
Bimodal age-specific incidence - 15 to 30 years of age; greater than 55 years of age
Cause unknown
Key factors
Infection with Epstein-Barr virus (EBV)
Genetic predisposition
Exposure to occupational toxins
Reed-Sternberg cell present in lymph node biopsy
Proliferate in the lymph nodes
Long-term survival exceeds 80% for all stages
Immunodeficiency states - HIV/AIDS
Leukemia - ANS-A group of cancers affecting the blood and blood-forming tissues of
bone marrow, lymph system and spleen
Uncontrolled production of WBCs
Usually fatal if untreated
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