The germ cells in the testicular tubules are actively dividing in the process of
spermatogenesis. A haploid set of chromosomes is formed in meiosis at the end
of which of the following phases?
A Metaphase II
B Prophase I
C Interphase II
D Telophase I
E Anaphase II
Answer: (D). The centromeres do not duplicate and divide, so when the chromosomes
pull apart, only one set is left in each daughter cell.
The process of gametogenesis is occurring in the ovary. A primary oocyte prior
to the start of hormonal cycles and hormonal stimulation is in which of the
following phases?
A Interphase II
B Prophase I
C Anaphase II
D Telophase I
E Metaphase II
Answer: (B). The oocyte is essentially in a holding pattern from before birth until
ovulation occurs in reproductive years, and can remain arrested at the diplotene phase
of prophase in meiosis I for decades. Spermatozoa, in contrast, are constantly being
produced through post-pubertal years of a male, and are not on hold.
A 25-year-old man and his 24-year-old wife have a baby boy who has a
problem with bowel obstruction soon after birth, but an otherwise uneventful
infancy. In childhood, however, their son has a succession of respiratory tract
infections. Laboratory workup fails to reveal an immunologic deficit. Their
daughter, born two years later, does not have these problems. There is no
family history for this disorder. Their son is infertile; their daughter gives birth
to a son and daughter, both of whom are not affected by this disorder. Which of
the following is the most likely pattern of inheritance for this family?
A Autosomal dominant
B Autosomal recessive
C Dominant negative
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