Stahl's psychopharm Chapter 2 Exam 2 Questions and Correct Answers, Updated 2024.
A 12 transmembrane region TRANSPORTER
30% of psychotropic drugs (wagon) SSRI's
7-transmembrane G-protein linked RECEPTOR
30% of all psychotropic drugs (receptor with 7 on it)
antipsychotics, anxiolytics
Enzyme...
Stahl's psychopharm Chapter 2 Exam 2
Questions and Correct Answers, Updated 2024.
A 12 transmembrane region TRANSPORTER
30% of psychotropic drugs (wagon) SSRI's
7-transmembrane G-protein linked RECEPTOR
30% of all psychotropic drugs (receptor with 7 on it)
antipsychotics, anxiolytics
Enzymes account for ENZYME
10% of all psychotropic drugs (ghost)
4 transmembrane region ligand gated ion channel
20% of psychotropic drugs (drum) PCP, benzo's
6 transmembrane region voltage gated ion channel
10% of all psychotropic drugs microphone)
There are 2 major subclasses of plasma membrane transporters
SLC6 gene family (for the monoamines serotonin, NE, and dopamine and for
neurotransmitters GABA and amino acid glycine.
SLC1(high affinity glutamate transporters)
There are 3 classes of intracellular synaptic vesicle neurotransmitter transporters
SLC18 (VMATs)- serotonin, NE, dopamine
(VAChT) histamine and acetylcholine
SLC32 (VIAAts) inhibitory amino acids
SLC17 (VGluT1-3) glutamate transporters
SERT, NET, DAT
unique presynaptic transporters...then they are transported into synaptic vesicles ALL
with the same transporter VMAT2
Monoamine transporters
Neurotransmitter sodium symporters, driven by diff in Na+ gradient
12 transmembrane domains
NET, DAT, SERT
What does allosteric mean?
other sites; mimicking or blocking can change gene expression and have profound
actions of psychiatric symptoms
Most common action in psych is to modify which receptors?
G-protein linked receptors; which can result in therapeutic actions or side effects
Transporter VMAT2 (SLC18 GENE)
SERT, NET, DAT
SLC6
plasma membrane transporters serotonin, norepi, dopamine, GABA, glycine
SLC1
Glutamate transporters
SLC18
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